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Full-Text Articles in Mechanical Engineering
Pymoocfd - A Multi-Objective Optimization Framework For Cfd, George Martin Cunningham Love
Pymoocfd - A Multi-Objective Optimization Framework For Cfd, George Martin Cunningham Love
Graduate College Dissertations and Theses
Modern computational resource have solidified the use of computer modeling as an integral part of the engineering design process. This is particularly impressive when it comes to high-dimensional models such as computational fluid dynamics (CFD) models. CFD models are now capable of producing results with a level of confidence that would previously have required physical experimentation. Simultaneously, the development of machine learning techniques and algorithms has increased exponentially in recent years. This acceleration is also due to the widespread availability of modern computational resources. Thus far, the cross-over between these fields has been mostly focused on computer models with low …
Medical Applications Of Ultrasound: T-Cell Drug Delivery, Osteoporosis Diagnosis, And Biofilm Mitigation, Alina Karki
Medical Applications Of Ultrasound: T-Cell Drug Delivery, Osteoporosis Diagnosis, And Biofilm Mitigation, Alina Karki
Graduate College Dissertations and Theses
The ability of ultrasound to localize acoustic energy deposition and induce a biological effect within a target is examined in three novel biomedical applications: sonoporation, osteoporosis diagnosis, and biofilm mitigation.Ultrasound can excite encapsulated microbubbles, causing an acoustic cavitation effect in the vicinity of cells, temporarily increasing membrane permeability, and allowing cells to uptake foreign molecules. This non-viral transfection technique is called sonoporation. Our experimental study demonstrated that it could be effective for small interfering RNA (siRNA) delivery into an isolated mouse and human T-cells, which is a complex process despite its importance in treating numerous diseases. T-cells are non-proliferating, while …