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Full-Text Articles in Mechanical Engineering
Effects Of Grooves On Drag In Laminar Channel Flow, Yanbei Wang
Effects Of Grooves On Drag In Laminar Channel Flow, Yanbei Wang
Electronic Thesis and Dissertation Repository
This thesis presents the analysis of the effects of three-dimensional grooves on the flow responses in laminar channel flows. The wall topographies were expressed using the two-dimensional Fourier expansions. A spectrally accurate algorithm based on the Immersed Boundary Conditions (IBC) was used to determine the solution for the field equations and extract information about the velocity and pressure fields. The effects of grooves on the pressure losses were assessed by determining the additional pressure gradient required to maintain the same flow rate through the grooved channel as through the reference smooth channel. Effects of groove wave numbers, groove amplitudes, the …
Scaffold Structural Microenvironmental Cues To Guide Tissue Regeneration In Bone Tissue Applications, Xuening Chen, Hongyuan Fan, Xiaowei Deng, Lina Wu, Tao Yi, Linxia Gu, Changchun Zhou, Yujiang Fan, Xingdong Zhang
Scaffold Structural Microenvironmental Cues To Guide Tissue Regeneration In Bone Tissue Applications, Xuening Chen, Hongyuan Fan, Xiaowei Deng, Lina Wu, Tao Yi, Linxia Gu, Changchun Zhou, Yujiang Fan, Xingdong Zhang
Department of Mechanical and Materials Engineering: Faculty Publications
In the process of bone regeneration, new bone formation is largely affected by physico-chemical cues in the surrounding microenvironment. Tissue cells reside in a complex scaffold physiological microenvironment. The scaffold should provide certain circumstance full of structural cues to enhance multipotent mesenchymal stem cell (MSC) differentiation, osteoblast growth, extracellular matrix (ECM) deposition, and subsequent new bone formation. This article reviewed advances in fabrication technology that enable the creation of biomaterials with well-defined pore structure and surface topography, which can be sensed by host tissue cells (esp., stem cells) and subsequently determine cell fates during differentiation. Three important cues, including scaffold …