Open Access. Powered by Scholars. Published by Universities.®
- Publication
Articles 1 - 2 of 2
Full-Text Articles in Mechanical Engineering
Characterizing Mechanical Regulation Of Bone Metastatic Breast Cancer Cells, Boyuan Liu
Characterizing Mechanical Regulation Of Bone Metastatic Breast Cancer Cells, Boyuan Liu
Doctoral Dissertations
Breast cancer most frequently metastasizes to the skeleton. Bone metastatic cancer is incurable and induces wide-spread bone osteolysis, resulting in significant patient morbidity and mortality. Mechanical stimuli in the skeleton are an important microenvironmental parameter that modulates tumor formation, osteolysis, and tumor cell-bone cell signaling, but which mechanical signals are the most beneficial and the corresponding molecular mechanisms are unknown. This work focused on bone matrix deformation and interstitial fluid flow based on their well-known roles in bone remodeling and in primary breast cancer. The goal of our research was to establish a platform that could define the relationship between …
The Effects Of Mechanical Loading And Tumor Factors On Osteocyte Dendrite Formation, Wenbo Wang
The Effects Of Mechanical Loading And Tumor Factors On Osteocyte Dendrite Formation, Wenbo Wang
Masters Theses
Advanced breast cancer predominantly metastasizes to the skeleton, at which point patients suffer bone loss, pain, heightened fracture risk and their prognosis significantly declines. The skeleton is sensitive to its highly dynamic mechanical environment whereby bone mass is increased when applied loads are increased whereas bone loss occurs when applied loads are reduced. Increased mechanical loading inhibited bone metastatic tumor formation and progression in vivo, but the underlying mechanisms are currently under investigation. Here, we focus on the osteocyte, a specialized bone cell well-known as the primary mechanosensor and director of remodeling in the skeleton. Osteocytic dendrites are important for …