Mechanical Engineering Commons^™

Use Of Bioheat Modeling To Characterize And Optimize Implantable Medical Devices And Neuromodulation Technologies, Adantchede Louis Zannou

Dissertations and Theses

Medical device development includes prototyping, benchtop characterization, preclinical studies, and clinical trials. Understanding the limitations and potential adverse effects of medical devices prior to their administration in humans is a crucial first step. Optimizing medical devices is essential to employing technology and improving patients care. Computational modeling is widely adopted as a powerful tool to predict stimulation/recording parameter optimization, rapid electrode/device prototyping, investigating novel mechanism of action, and testing working principles of any medical devices. Many implantable neuromodulation technologies including Spinal Cord Stimulation (SCS), which provide substantial therapeutic benefit for patient population with lower back pain, produces heat via the …

Adhesively Bonded Multi-Material Single Lap Joints Under Static Tensile Loading, Yesim Kokner

Dissertations and Theses

Adhesive joints are widely used in a variety of industrial applications utilizing the improved mechanical properties they provide over traditional mechanical joining methods. [1] The lap joint is a usual test specimen with a view to assessing the strength and properties of joints.

This study deals with the stiffness, strength and fracture behavior of multi-material single-lap joints. It describes the mechanical behavior of a multi-material single lap joints subjected to static tensile loading in the longitudinal direction. First, steel-to-steel and aluminum-to-aluminum joints are tested to establish baseline data. Subsequently, multi-material joints consisting of aluminum-to-steel, aluminum-to-composite, and steel-to-composite joints were tested …

The Study Of 3d Micro-Fluid Printing In Aqueous Two-Phase System, Mian Huang

Dissertations and Theses

Aqueous two-phase system (ATPS) is a technology that allows phase separation in an aqueous environment. This technology can be used for the separation, extraction and purification of a variety of biomolecules and thus gained great attention in industry and academia. This thesis is a combination of ATPS, 3D printing, and microfluidics technologies and realizes the printing of biocompatible aqueous structures in another aqueous matrix. The objectives of this thesis include 1) customizing a regular thermal extrusion 3D printer for printing 3D aqueous structures, 2) printing 3D aqueous structure in an aqueous matrix, and 3) studying the stability of the printed …

Morphology Of Brain Sulci Trabeculae And Its Effect On Brain During Impacts, Sharlin Anwar

Dissertations and Theses

Traumatic brain injury (TBI) is an intracranial injury caused by direct contact or non-contact head impacts to the brain. TBI is a major problem that accounts for high incidents of hospitalizations each year. Thus, it is important to understand and predict the occurrence of TBI in an impact. It has been shown that the subarachnoid space (SAS) trabeculae play an important role in damping the effect of an impact, thus reducing the injuries. However, the influence of sulci parameters and the sulci trabeculae in TBI due to impact is unexplored. Studies have shown that inclusion of sulci in brain models …

Computer Solution To Inverse Problems Of Elliptic Form: V²U(X,Y) = G(A,U,X,Y), Frederick Alvin Jeter

Dissertations and Theses

One important aspect of our present age of monolithic high speed computers is the computer's capability to solve complex problems hitherto impossible to tackle due to their complexity. This paper explains how to use a. digital computer to solve a specific type of problem; specifically, to find the inverse solution of a in the elliptical equation V²U(x,y) = g(a,U,x,y), with appropriate boundary conditions. This equation is very useful in the electronics field. The knowns are the complete set of boundary values of U(x,y) and a set of observations taken on internal points of U(x,y). Given this information, plus …

Direct Design Of A Portal Frame, Angel Fajardo Ugaz

Dissertations and Theses

This investigation was undertaken to develop plastic design aids to be used in the direct design of optimum frames. It uses the concept of minimum weight of plastically designed steel frames, and the concept of linear programming to obtain general solutions. Among the special characteristics of this study are: A. The integration of both gravity and combined loading conditions into one linear programming problem. B. The application of the revised simplex method to the dual of a parametric original problem. C. The application of A and B above in the development of design aids for the optimum design of symmetrical …