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Full-Text Articles in Mechanical Engineering
A Microflow Cytometer On A Chip, Joel P. Golden, Jason Kim, George P. Anderson, Nicole N. Hashemi, Peter J. Howell, Frances S. Ligler
A Microflow Cytometer On A Chip, Joel P. Golden, Jason Kim, George P. Anderson, Nicole N. Hashemi, Peter J. Howell, Frances S. Ligler
Nastaran Hashemi
A rapid, automated, multi-analyte Microflow Cytometer is being developed as a portable, field-deployable sensor for onsite diagnosis of biothreat agent exposure and environmental monitoring. The technology relies on a unique method for ensheathing a sample stream in continuous flow past an interrogation region where optical fibers provide excitation and collect emission. This approach efficiently focuses particles in the interrogation region of the fluidic channel, avoids clogging and provides for subsequent separation of the core and sheath fluids in order to capture the target for confirmatory assays and recycling of the sheath fluid. Fluorescently coded microspheres provide the capability for highly …
The Dissipated Power In Atomic Force Microscopy Due To Interactions With A Capillary Fluid Layer, Nicole N. Hashemi, M.R. Paul, H. Dankowicz, W. Jhe
The Dissipated Power In Atomic Force Microscopy Due To Interactions With A Capillary Fluid Layer, Nicole N. Hashemi, M.R. Paul, H. Dankowicz, W. Jhe
Nastaran Hashemi
We study the power dissipated by the tip of an oscillating micron-scale cantilever as it interacts with a sample using a nonlinear model of the tip-surface force interactions that includes attractive, adhesive, repulsive, and capillary contributions. The force interactions of the model are entirely conservative and the dissipated power is due to the hysteretic nature of the interaction with the capillary fluid layer. Using numerical techniques tailored for nonlinear and discontinuous dynamical systems we compute the exact dissipated power over a range of experimentally relevant conditions. This is accomplished by computing precisely the fraction of oscillations that break the fluid …