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Articles 1 - 5 of 5
Full-Text Articles in Mechanical Engineering
Fabrication And Characterization Of Poly(Octanediol Citrate)/Gallium-Containing Bioglass Microcomposite Scaffolds
Faculty of Engineering University of Malaya
Bone can be affected by osteosarcomae requiring surgical excision of the tumor as part of the treatment regime. Complete removal of cancerous cells is difficult and conventionally requires the removal of a margin of safety around the tumor to offer improved patient prognosis. This work considers a novel series of composite scaffolds based on poly(octanediol citrate) (POC) impregnated with gallium-based bioglass microparticles for possible incorporation into bone following tumor removal. The objective of this research was to fabricate and characterize these scaffolds and subsequently report on their mechanical and biological properties. The porous microcomposite scaffolds with various concentrations of bioglass …
A Glass Polyalkenoate Cement Carrier For Bone Morphogenetic Proteins
A Glass Polyalkenoate Cement Carrier For Bone Morphogenetic Proteins
Faculty of Engineering University of Malaya
This work considers a glass polyalkenoate cement (GPC)-based carrier for the effective delivery of bone morphogenetic proteins (BMPs) at an implantation site. A 0.12 CaO-0.04 SrO-0.36 ZnO-0.48 SiO2 based glass and poly(acrylic acid) (PAA, Mw 213,000) were employed for the fabrication of the GPC. The media used for the water source in the GPC reaction was altered to produce a series of GPCs. The GPC liquid media was either 100 % distilled water with additions of albumin at 0, 2, 5 and 8 wt% of the glass content, 100 % formulation buffer (IFB), and 100 % BMP (150 mu g …
Processing And Analysis Of Chitosan Nanocomposites Reinforced With Chitin Whiskers And Tannic Acid As A Crosslinker
Faculty of Engineering University of Malaya
Chitosan film reinforced with nano-sized chitin whiskers and crosslinked using tannic acid was synthesized by the casting-vaporation method. The mechanical and physicochemical properties of several film samples (consisting of different ratio of chitin and tannic acid) were compared with neat chitosan. Tensile tests show that the addition of chitin improves the nanocomposite films mechanical properties up to 137% compared to neat chitosan, but this is slightly degraded when tannic acid is introduced. However, tannic acid and chitin whisker content greatly reduced moisture content by 294% and water solubility by 13%. Transmission electron microscopy (TEM) and Fourier-transform-infrared spectroscopy (FTIR) were used …
Guided Routing On Spinning Microfluidic Platforms
Guided Routing On Spinning Microfluidic Platforms
Faculty of Engineering University of Malaya
Flow directionality, valving and liquid routing in centrifugal microfluidics (Lab-on-CD) are typically controlled by applying centrifugal and Coriolis forces and have been the subject of active research interest in recent years. Determining and switching the flow direction at a T-junction is a common fluidic operation important for implementing several chemical and clinical assays for Lab-on-CDs. The present work describes a novel approach to route samples and control flow direction on a spinning disc that employs a guiding microstructure that relies on a two-stage valve comprised of an auxiliary inlet, which is a recess embedded at a T-junction, and a bent …
Improved Friction And Wear Performance Of Micro Dimpled Ceramic-On-Ceramic Interface For Hip Joint Arthroplasty
Faculty of Engineering University of Malaya
The purpose of this study is to investigate the tribological effect of micro-dimpled surface textures for application in ceramic-on-ceramic hip prostheses. A rectangular array of circular dimples was selected as the texture pattern. A CNC micro drilling machine was used to fabricate these dimples on a flat ceramic substrate. Tribology tests were performed by using a pin-on-disk method with selected hertzian contact pressures and speeds based on normal gait of a hip joint, and results compared with non-dimpled surface. A dimpled surface with large dimple diameters and a high dimple density (phi 400 mu m and density 15%) showed significant …