Mechanical Engineering Commons^™

Accurate Replication Of An Ear Pinnae Geometry For Use In Acoustic Testing Of Spatial Cues And Sound Localization, Alejandra Belmont

Open Access Theses & Dissertations

Additive manufacturing (AM) enables freedom of design as well as fabrication of complex objects such as the human hear. In medical modeling there is a need for patient-specific customizable parts. The outer human ear consists of these main parts: the pinna, which naturally filters sound, and the ear canal, which is the point at which sound enters before being moved up to the tympanic membrane, otherwise known as the eardrum. In an attempt to accurately replicate ear models, the use of scanning and reverse engineering methods was used. A comparison of 3D laser scanning systems was performed to determine their …

Redesign Of A Volume Adjustable Transtibial Prosthetic Socket, Samuel Terrazas Quezada

Open Access Theses & Dissertations

Recent research and development in prosthetics have aimed at improving socket designs and components to mimic more efficiently the human body. One such innovation is the Aperture Socket, a low-cost volume adjustable prosthetic socket. During the validation stage of its development, the Aperture Socket successfully demonstrated that it could compensate for volume changes, but various improvements on use and comfort were identified. This project develops and tests a redesign of the Aperture Socket previously developed for amputees in developing countries and subsequently patented and licensed to LIMBS International, Inc.

The first phase of this study was the creation of various …

Design And Development Of Implantable And Remote Controlled Distraction Osteogenesis Device For Limb Lengthening Practice In Children, Mario Eduardo Rodriguez De La O

Open Access Theses & Dissertations

Recent technology improvements have been positively affecting medical industry in recent years since procedures and equipment are more precise and reliable. Nevertheless, there are still surgical procedures and medical devices that not fully address specific needs according to medical experts. One of those necessities is focused on options available for children patients when subjected to a surgical procedure named distraction osteogenesis. In general, distraction osteogenesis is performed when skeletal deformities need to be corrected or when bone lengthening is required, typically a mechanism is utilized to elongate bone at a controlled rate. The existing osteodistraction methods for limb lengthening and …

Inkjet Based Personalized Screening Platform For Cancer Therapy, Jorge Ivan Rodriguez

Open Access Theses & Dissertations

The new paradigm of personalized medicine is beginning to affect clinical practice. In particular, many of the advances in genomics and proteomics have made personalized screening and therapeutic inventions possible. On chip, cellomics approaches to screening and intervention are becoming more commonplace. Cancer therapies may benefit from the rise in `-omics' technologies. In addition, the availability of rapid screening data is crucial to mitigate cancer propagation and increase the possibility of patient recovery. This study is an endeavor to develop a cellomic anticancer drug screening process based on inkjet printing. Previous research has demonstrated that inkjet based screening can reliably …

Scaffold Based In-Vitro Osteodistraction For Bone Tissue Engineering, Cesar Adrian Terrazas

Open Access Theses & Dissertations

Engineering of hard tissues such as bone is a challenge because of the limited ability of the body to heal large defects. Current treatment options, such as employing bone sections from the patient or a deceased donor have been utilized for some time now with various degrees of success. However, these methods still exhibit many limitations such as limited supply and the possibility of transmission of disease.

To address the many limitations of bone grafts, synthetic engineered substitutes have been developed and widely researched for nearly three decades. Generally termed scaffolds, these are matrices that serve the purpose of temporary …

Multidisciplinary Collaborative Model For Complex, Angel Ernesto Delgado

Open Access Theses & Dissertations

Nowadays, most devices with advanced technology require the development of embedded systems with mechanical and electrical components as well as software including more than one discipline. These are devices that are usually complex in terms of composition and functionality and that design must follow a methodology in order to successfully design and launch a device of this nature. Hence, the assembly of a multidisciplinary engineering group is required to carry out such complex devices and develop a fully functional product. The group may also need an expert on the field that can provide guidance and knowledge where needed. This is …

Stereolithography Of Poly(Ethylene Glycol) Hydrogels With Application In Tissue Engineering As Peripheral Nerve Regeneration Scaffolds, Karina Arcaute

Open Access Theses & Dissertations

In recent years, rapid prototyping (RP) technologies initially developed to create prototypes prior to production for the automotive, aerospace, and other industries, have found applications in tissue engineering (TE). Several different RP technologies are being used to fabricate biocompatible 3D structures with controlled micro- and macro-scale characteristics. The focus of this research was to explore the capabilities of the RP technology, stereolithography (SL), for creating complex, 3D scaffolds with applications in TE using a photocrosslinkable biopolymer, poly(ethylene glycol) (PEG). The primary objective was to create an implantable multi-lumen nerve guidance conduit (NGC) for the regeneration of peripheral nerves.

Studies of …