Mechanical Engineering Commons^™

Stress And Strain Adaptation In Load-Dependent Remodeling Of The Embryonic Left Ventricle, Christine Buffinton

Faculty Journal Articles

Altered pressure in the developing left ventricle (LV) results in altered morphology and tissue material properties. Mechanical stress and strain may play a role in the regulating process. This study showed that confocal microscopy, three-dimensional reconstruction, and finite element analysis can provide a detailed model of stress and strain in the trabeculated embryonic heart. The method was used to test the hypothesis that end-diastolic strains are normalized after altered loading of the LV during the stages of trabecular compaction and chamber formation. Stage-29 chick LVs subjected to pressure overload and underload at stage 21 were reconstructed with full trabecular morphology …

Prediction Of Articular Cartilage Remodeling During Dynamic Compression With A Finite Element Model, Kevin Akira Yamauchi

Master's Theses

First, an in vitro growth experiment was performed to test the hypothesis that applying dynamic unconfined compression during culture produces het- erogeneous remodeling in newborn bovine articular cartilage explants. Het- erogeneous measures of cartilage microstructure were obtained by biochemical assays and quantified polarized light microscopy. Significant differences were measured between the GAG content in the inner and outer portions of the sam- ples stimulated with dynamic unconfined compression. The COL fiber network was found to be more highly aligned in the inner portion of the sample than in the peripheral region.

Next, a poroelastic finite element model with a remodeling …

Finite Element Analysis Of A Femur To Deconstruct The Design Paradox Of Bone Curvature, Sameer Jade

Masters Theses 1911 - February 2014

The femur is the longest limb bone found in humans. Almost all the long limb bones found in terrestrial mammals, including the femur studied herein, have been observed to be loaded in bending and are curved longitudinally. The curvature in these long bones increases the bending stress developed in the bone, potentially reducing the bone’s load carrying capacity, i.e. its mechanical strength. Therefore, bone curvature poses a paradox in terms of the mechanical function of long limb bones. The aim of this study is to investigate and explain the role of longitudinal bone curvature in the design of long bones. …

Investigating The Relationship Between Material Property Axes And Strain Orientations In Cebus Apella Crania, Christine M. Dzialo

Masters Theses 1911 - February 2014

Probabilistic finite element analysis was used to determine whether there is a statistically significant relationship between maximum principal strain orientations and orthotropic material stiffness orientations in a primate cranium during mastication. We first sought to validate our cranium finite element model by sampling in-vivo strain and in-vivo muscle activation data during specimen mastication. A comparison of in vivo and finite element predicted (i.e. in silico) strains was performed to establish the realism of the FEM model. To the best of our knowledge, this thesis presents the world’s only complete in-vivo coupled with in-vitro validation data set of a primate cranium …