Mechanical Engineering Commons^™

Microfluidics Design Considering Hyperuniformity And Cell Transport In Flow For Improved Circulating Tumor Cell Capture Efficiency, Michael Clarence Hood

Graduate Research Theses & Dissertations

Isolation of circulating tumor cells (CTCs) from patient derived blood samples for cancerdiagnostics and monitoring is challenging due to the extremely low CTC concentration. This thesis work evaluates the performance of passive microfluidics devices with different designs based on computational modeling. A new cell separation method is proposed based on velocity differentiation of varying cell sizes. All numerical studies were conducted in 2D based on a fluid structure interaction code where the fluid flow was solved based on the lattice Boltzmann method (LBM) implemented in Palabos, and the cell dynamics were simulated based on the molecular dynamics package LAMMPS, with …

Dynamic Behavior And Interactions Of Ferrofluid Droplets Under Magnetic Fields In Low Reynolds Number Flows, Md Rifat Hassan

Doctoral Dissertations

Digital microfluidics in combination with emulsion microfluidics are crucial building blocks of droplet-based microfluidics, which are prevalent in a wide variety of industrial and biomedical applications, including polymer processing, food production, drug delivery, inkjet printing, and cell-based assays. Therefore, understanding the dynamics and interactions of droplets as well as the interactions between the droplets and solid surfaces are of great importance in order to improve the performance or product in these applications.

Recently, several studies in the literature have demonstrated the potential of magnetic fields in controlling the behavior of droplets in microscale; however, the fundamental mechanism behind the interesting …

Magnetic Control Of Transport Of Particles And Droplets In Low Reynolds Number Shear Flows, Jie Zhang

Doctoral Dissertations

“Magnetic particles and droplets have been used in a wide range applications including biomedicine, biological analysis and chemical reaction. The manipulation of magnetic microparticles or microdroplets in microscale fluid environments is one of the most critical processes in the systems and platforms based on microfluidic technology. The conventional methods are based on magnetic forces to manipulate magnetic particles or droplets in a viscous fluid.

In contrast to conventional magnetic separation method, several recent experimental and theoretical studies have demonstrated a different way to manipulate magnetic non-spherical particles by using a uniform magnetic field in the microchannel. However, the fundamental mechanism …

Microfluidic Biosensor With Functionalized Gold Nano Particles On Interdigitated Electrodes, Bharath Babu Nunna

Dissertations

The integration of the microfluidics to the biosensor has growing demand with favorable conditions such as reduced processing time and low reagent consumption. The immuno biosensing with the microfluidic platform helped to make the electrochemical biosensing assays portable due to which this sensing mechanism can be easily implemented in point of care devices. The implementation of the biosensing in the microchannels significantly reduces the sample requirement form milli liter (mL) to micro liter (uL), and thus leads to low volume sample requirement during the sensing. The primary factors contributing to the microfluidic biosensors performance are probe immobilization, specific binding and …