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- Amphiphilic graft copolymers (2)
- Ring-opening metathesis polymerization (2)
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Articles 1 - 6 of 6
Full-Text Articles in Materials Science and Engineering
Mechanics Of Hydrogels And Biological Tissues, Jessica A. Zimberlin
Mechanics Of Hydrogels And Biological Tissues, Jessica A. Zimberlin
Open Access Dissertations
The relationship between cells and their environment is one of dynamic reciprocity, whereby cells can influence their surrounding and the surroundings can influence the cells. One example of this relationship arises from the effect of the mechanical properties of an environment on a cell and of a cell on its environment. Inspired by this relationship, we investigate 1) the local environment of biological materials, both native and synthetic, and 2) the forces that cell sheets exert on surfaces. We do this by developing techniques that focus on local mechanical properties and experimental strategies that provide insight into intercellular mechanics. We …
Atomic-Scale Analysis Of Plastic Deformation In Thin-Film Forms Of Electronic Materials, Kedarnath Kolluri
Atomic-Scale Analysis Of Plastic Deformation In Thin-Film Forms Of Electronic Materials, Kedarnath Kolluri
Open Access Dissertations
Nanometer-scale-thick films of metals and semiconductor heterostructures are used increasingly in modern technologies, from microelectronics to various areas of nanofabrication. Processing of such ultrathin-film materials generates structural defects, including voids and cracks, and may induce structural transformations. Furthermore, the mechanical behavior of these small-volume structures is very different from that of bulk materials. Improvement of the reliability, functionality, and performance of nano-scale devices requires a fundamental understanding of the atomistic mechanisms that govern the thin-film response to mechanical loading in order to establish links between the films' structural evolution and their mechanical behavior. Toward this end, a significant part of …
Oligopeptide-Functionalized Graft Copolymers: Synthesis And Applications In Nucleic Acid Delivery, Rebecca Boudreaux Breitenkamp
Oligopeptide-Functionalized Graft Copolymers: Synthesis And Applications In Nucleic Acid Delivery, Rebecca Boudreaux Breitenkamp
Open Access Dissertations
Utilizing the diverse functionality of amino acids, a new class of amphiphilic graft copolymers has been synthesized, characterized, and explored for applications in biomaterials and nucleic acid delivery. This thesis research focused on the syntheses of oligopeptide-functionalized polyesters and polyolefins. Polyester functionalization was geared towards applications in biomaterials, tissue engineering, and drug delivery by incorporating sequences that promote cell-adhesion. These polyester- graft -oligopeptide materials were prepared by a 1,3-Huisgen cycloaddition reaction, "click" chemistry, of an azide-terminated oligopeptide (prepared by Fmoc-based solid phase peptide synthesis (SPPS)) and alkyne-containing polyester (synthesized by ring-opening polymerization). Following the syntheses of these materials, they were …
Polymer Confinement And Translocation, Chiu Tai Andrew Wong
Polymer Confinement And Translocation, Chiu Tai Andrew Wong
Open Access Dissertations
Single polymer passage through geometrically confined regions is ubiquitous in biology. Recent technological advances have made the direct study of its dynamics possible. We studied the capture of DNA molecules by the electroosmotic flow of a nanopore induced by its surface charge under an applied electric field. We showed theoretically that the DNA molecules underwent coil-stretch transitions at a critical radius around the nanopore and the transition assisted the polymer passage through the pore. To understand how a polymer worms through a narrow channel, we investigated the translocation dynamics of a Gaussian chain between two compartments connected with a cylindrical …
Synthesis And Interfacial Behavior Of Functional Amphiphilic Graft Copolymers Prepared By Ring-Opening Metathesis Polymerization, Kurt E. Breitenkamp
Synthesis And Interfacial Behavior Of Functional Amphiphilic Graft Copolymers Prepared By Ring-Opening Metathesis Polymerization, Kurt E. Breitenkamp
Open Access Dissertations
This thesis describes the synthesis and application of a new series of amphiphilic graft copolymers with a hydrophobic polyolefin backbone and pendent hydrophilic poly(ethylene glycol) (PEG) grafts. These copolymers are synthesized by ruthenium benzylidene-catalyzed ring-opening metathesis polymerization (ROMP) of PEG-functionalized cyclic olefin macromonomers to afford polycyclooctene- graft -PEG (PCOE- g -PEG) copolymers with a number of tunable features, such as PEG graft density and length, crystallinity, and amphiphilicity. Macromonomers of this type were prepared first by coupling chemistry using commercially available PEG monomethyl ether derivatives and a carboxylic acid-functionalized cycloctene. In a second approach, macromonomers possessing a variety of PEG …
Effect Of Loading And Process Conditions On The Mechanical Behavior In Sebs Thermoplastic Elastomers (Tpes), Mohit Mamodia
Effect Of Loading And Process Conditions On The Mechanical Behavior In Sebs Thermoplastic Elastomers (Tpes), Mohit Mamodia
Open Access Dissertations
Styrenic block copolymer thermoplastic elastomers are one of the most widely used thermoplastic elastomers (TPEs) today. The focus of this research is to fundamentally understand the structure-processs-property relationships in these materials. Deformation behavior of the block copolymers with cylindrical and lamellar morphologies has been investigated in detail using unique techniques like deformation calorimetry, transmission electron microscopy (TEM), combined in-situ small angle x-ray and wide angle x-ray scattering (SAXS/WAXS). The research involves the study of structural changes that occur at different length scales along with the energetics involved upon deformation. The structural changes in the morphology of these systems on deformation …