Materials Science and Engineering Commons^™

Immune Modulation By Amphiphilic Oligonucleotides, Chunsong Yu

Wayne State University Dissertations

Immunotherapy is emerging as one of the most promising therapeutic strategies for cancer treatment in clinical practice. Immunotherapy leverages the host’s immune system to attack and kill tumor cells. Rationally-designed cancer vaccines are emerging as one of the powerful immunotherapies primarily because of the promise of inducing tumor antigen-specific immune responses. To improve immunogenicity of cancer vaccines, vaccine antigens are administered with vaccine adjuvants which can robustly activate innate immune system and subsequently lead to adaptive immune response. However, the major challenge of achieving significant therapeutic efficacy is lack of efficient targeted-delivery of vaccine components. By taking advantage of endogenous …