Materials Science and Engineering Commons^™

The Impact Of A Dynamic Environment On Deposition And Cellular Response To Silver Nanoparticles, Robert F. Uhrig

Honors Theses

Silver nanoparticles (AgNPs) are utilized in many different applications, such as an antibacterial agents or as protective coating against ultraviolet light. However, these AgNPs are known to cause potentially harmful biological effects, including toxicity, induction of stress, and immune activation. In this study, the effects of AgNPs on a human lung cell model were examined within both a static and dynamic environment. Most NP-based research is carried out in static environments, but do not accurate reflect dynamic physiological conditions. Dynamic fluid movement was introduced to the cell culture through the use of a multi-channel peristaltic pump. To further characterize the …