Materials Science and Engineering Commons^™

The Role Of Metal Oxide Layers In The Sensitivity Of Lactate Biosensors Subjected To Oxygen-Limited Conditions, Elizabeth Andreasen, Lia Stanciu, Aytekin Uzunoglu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Amperometric lactate biosensors are used to detect lactate concentration in blood and tissues, which is integral in identifying cyanide poisoning, septic shock, and athletic condition. The construction of lactate biosensors with high sensitivity, selectivity, and stability is imperative to diagnose and determine these medical conditions. Lactate detection is currently limited to oxygen-rich environments due to the fact that oxygen is a limiting factor in the lactate reaction. To circumvent this problem, researchers have developed mediators or alternate, oxygen-free enzymes to improve sensitivity. In our study, ceria (CeO₂) with high oxygen storage capacity (OSC) was introduced to the enzyme …