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Full-Text Articles in Engineering Science and Materials
Development And Characterization Of Multi-Crosslinking Injectable Hydrogels For Use In Cell And Drug Delivery, Jennifer Etter
Development And Characterization Of Multi-Crosslinking Injectable Hydrogels For Use In Cell And Drug Delivery, Jennifer Etter
Graduate College Dissertations and Theses
Injectable hydrogels are important for use in tissue engineering due to their permeability and biocompatibility. Those that have shear thinning properties allow for minimally-invasive surgical procedures and a way to administer bioactive agents, and therapeutic cells by injection. Currently available injectable hydrogels have a single or dual input/stimulus for crosslinking which limits the range of mechanical properties and often utilize potentially toxic ultraviolet radiation that reduces viability of injected cells. To overcome these shortcomings, a tri-stimuli-responsive alginate-based injectable hydrogel was developed based on: 1) supramolecular complex formation between β-cyclodextrin (β-CD) conjugated alginate and thermo-responsive tri-block Pluronic® copolymers, 2) visible light …
Design, Prototyping And Fabrication Of Powder Spray Device For Dehydrated Biological Particulates, James Reilly
Design, Prototyping And Fabrication Of Powder Spray Device For Dehydrated Biological Particulates, James Reilly
Graduate College Dissertations and Theses
Tissue sealants of a liquid based formulation are widely studied in biomedical research with many starting to gain FDA approval. To date, little investigation has been put toward methods of application for tissue sealant materials, more specifically a powder based formulation. The focus of this research was to develop and prototype a powder spray device capable of administering powder based formulations with a long-term goal of integrating the device within the clinical setting. Powders can be administered in a variety of dry forms. These forms can range from non-homogenous nanoscale particles to homogeneous micro and nano-scale spheres. Incorporation of therapeutics …