Engineering Science and Materials Commons^™

Electrokinetic Manipulation Of Particles And Cells In Microfluidic Devices, Christopher Church

All Theses

With the recent advancement in micro-fabrication technology, lab-on-a-chip devices have been developed in order to perform biological analysis through cell manipulation. Microchannels used in these lab-on-a-chip devices have been demonstrated to accurately perform many different cell manipulation techniques such as focusing, separation, trapping, and lysis. Although there are many methods available for these techniques, electrokinetics has been rapidly gaining popularity due to the simplicity of application and removal of the need for in channel micro-structures. This thesis studies the use of electrokinetic flow and accompanying phenomena in various structured microchannels to perform focusing, separation, trapping, and lysis of cells. Three …