Engineering Science and Materials Commons^™

Testing Oxygenated Microbubbles Via Intraperitoneal And Intrathoracic Routes On A Large Pig Model Of Lps-Induced Acute Respiratory Distress Syndrome, Riaz Ur Rehman Mohammed, Nathaniel T. Zollinger, Andrea R. Mccain, Roser Romaguera-Matas, Seth P. Harris, Keely L. Buesing, Mark A. Borden, Benjamin S. Terry

Department of Mechanical and Materials Engineering: Faculty Publications

With a mortality rate of 46% before the onset of COVID-19, acute respiratory distress syndrome (ARDS) affected 200,000 people in the US, causing 75,000 deaths. Mortality rates in COVID-19 ARDS patients are currently at 39%. Extrapulmonary support for ARDS aims to supplement mechanical ventilation by providing life-sustaining oxygen to the patient. A new rapid-onset, human-sized pig ARDS model in a porcine intensive care unit (ICU) was developed. The pigs were nebulized intratracheally with a high dose (4 mg/kg) of the endotoxin lipopolysaccharide (LPS) over a 2 h duration to induce rapid-onset moderate-to- severe ARDS. They were then catheterized to monitor …