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Oxidation And Adsorption Of Deoxyribonucleic Acid At Highly Ordered Pyrolytic Graphite And Glass Carbon Electrode, Jianzhang Zhou, Lingling Wu, Jin Luo, Zhonghua Lin

Journal of Electrochemistry

It is shown that calf thymus DNA(CT DNA) can be adsorbed at highly ordered pyrolytic graphite(HOPG) electrode and detected by differential pulse voltammetry(DPV) and electrochemical atomic force microscopy(ECAFM). It is found that controlled potential pre-polarization influences largely the adsorption of dsDNA while it has little influence on ssDNA. It is demonstrated that ECAFM is useful to exploit adsorption of DNA at HOPGE. The pattern of adsorption of DNA at HOPG electrode that fits best with the experimental data is proposed. The results aslo shows that UV/Vis reflection spectroscopy, which has not been used in studying electrochemical behavior of DNA, is …