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Articles 1 - 8 of 8
Full-Text Articles in Electrical and Computer Engineering
Generation Of Dna Oligomers With Similar Chemical Kinetics Via In-Silico Optimization, Michael Tobiason, Bernard Yurke, William L. Hughes
Generation Of Dna Oligomers With Similar Chemical Kinetics Via In-Silico Optimization, Michael Tobiason, Bernard Yurke, William L. Hughes
Electrical and Computer Engineering Faculty Publications and Presentations
Networks of interacting DNA oligomers are useful for applications such as biomarker detection, targeted drug delivery, information storage, and photonic information processing. However, differences in the chemical kinetics of hybridization reactions, referred to as kinetic dispersion, can be problematic for some applications. Here, it is found that limiting unnecessary stretches of Watson-Crick base pairing, referred to as unnecessary duplexes, can yield exceptionally low kinetic dispersions. Hybridization kinetics can be affected by unnecessary intra-oligomer duplexes containing only 2 base-pairs, and such duplexes explain up to 94% of previously reported kinetic dispersion. As a general design rule, it is recommended that unnecessary …
Multiscaffold Dna Origami Nanoparticle Waveguides, William P. Klein, Charles N. Schmidt, Blake Rapp, Sadao Takabayashi, William B. Knowlton, Jeunghoon Lee, Bernard Yurke, William L. Hughes, Elton Graugnard, Wan Kuang
Multiscaffold Dna Origami Nanoparticle Waveguides, William P. Klein, Charles N. Schmidt, Blake Rapp, Sadao Takabayashi, William B. Knowlton, Jeunghoon Lee, Bernard Yurke, William L. Hughes, Elton Graugnard, Wan Kuang
Electrical and Computer Engineering Faculty Publications and Presentations
DNA origami templated self-assembly has shown its potential in creating rationally designed nanophotonic devices in a parallel and repeatable manner. In this investigation, we employ a multiscaffold DNA origami approach to fabricate linear waveguides of 10 nm diameter gold nanoparticles. This approach provides independent control over nanoparticle separation and spatial arrangement. The waveguides were characterized using atomic force microscopy and far-field polarization spectroscopy. This work provides a path toward large-scale plasmonic circuitry.
2x1d Image Registration And Comparison, Geng Zheng, Elisa H. Barney Smith, Nader Rafla, Tim Andersen
2x1d Image Registration And Comparison, Geng Zheng, Elisa H. Barney Smith, Nader Rafla, Tim Andersen
Electrical and Computer Engineering Faculty Publications and Presentations
This paper presents a novel 2x1D phase correlation based image registration method for verification of printer emulator output. The method combines the basic phase correlation technique and a modified 2x1D version of it to achieve both high speed and high accuracy. The proposed method has been implemented and tested using images generated by printer emulators. Over 97% of the image pairs were registered correctly, accurately dealing with diverse images with large translations and image cropping.
Chip-Scale Nanophotonic Chemical And Biological Sensors Using Cmos Process, Lincoln Bollschweiler, Alex English, R. Jacob Baker, Wan Kuang, Zi-Chang Chang, Ming-Hsiung Shih, William Knowlton
Chip-Scale Nanophotonic Chemical And Biological Sensors Using Cmos Process, Lincoln Bollschweiler, Alex English, R. Jacob Baker, Wan Kuang, Zi-Chang Chang, Ming-Hsiung Shih, William Knowlton
Electrical and Computer Engineering Faculty Publications and Presentations
A monolithic integrated chip-scale surface plasmon resonance (SPR) sensor is demonstrated. The device consists of a pn photodiode covered with a periodic modified thin metal film whose lattice constant is on the order of the wavelength of light. The device performs real-time measurement of resonant wavelengths of enhanced optical transmission due to surface plasmon resonance, which are influenced by the presence of chemical or biological materials at the device’s surface.
Hardware/Software Codesign In A Compact Ion Mobility Spectrometer Sensor Systemfor Subsurface Contaminant Detection, Sin Ming Loo, Jonathan P. Cole, Molly M. Gribb
Hardware/Software Codesign In A Compact Ion Mobility Spectrometer Sensor Systemfor Subsurface Contaminant Detection, Sin Ming Loo, Jonathan P. Cole, Molly M. Gribb
Electrical and Computer Engineering Faculty Publications and Presentations
A field-programmable-gate-array-(FPGA-) based data acquisition and control system was designed in a hardware/software codesign environment using an embedded Xilinx Microblaze soft-core processor for use with a subsurface ion mobility spectrometer (IMS) system, designed for detection of gaseous volatile organic compounds (VOCs). An FPGA is used to accelerate the digital signal processing algorithms and provide accurate timing and control. An embedded soft-core processor is used to ease development by implementing nontime critical portions of the design in software. The design was successfully implemented using a low-cost, off-the-shelf Xilinx Spartan-III FPGA and supporting digital and analog electronics.
Partitioning Of The Degradation Space For Ocr Training, Elisa H. Barney Smith, Tim Andersen
Partitioning Of The Degradation Space For Ocr Training, Elisa H. Barney Smith, Tim Andersen
Electrical and Computer Engineering Faculty Publications and Presentations
Generally speaking optical character recognition algorithms tend to perform better when presented with homogeneous data. This paper studies a method that is designed to increase the homogeneity of training data, based on an understanding of the types of degradations that occur during the printing and scanning process, and how these degradations affect the homogeneity of the data. While it has been shown that dividing the degradation space by edge spread improves recognition accuracy over dividing the degradation space by threshold or point spread function width alone, the challenge is in deciding how many partitions and at what value of edge …
A Study Of Style Effects On Ocr Errors In The Medline Database, Penny Garrison, Diane Davis, Tim Andersen, Elisa Barney Smith
A Study Of Style Effects On Ocr Errors In The Medline Database, Penny Garrison, Diane Davis, Tim Andersen, Elisa Barney Smith
Electrical and Computer Engineering Faculty Publications and Presentations
The National Library of Medicine has developed a system for the automatic extraction of data from scanned journal articles to populate the MEDLINE database. Although the 5-engine OCR system used in this process exhibits good performance overall, it does make errors in character recognition that must be corrected in order for the process to achieve the requisite accuracy. The correction process works by feeding words that have characters with less than 100% confidence (as determined automatically by the OCR engine) to a human operator who then must manually verify the word or correct the error. The majority of these errors …
Text Degradations And Ocr Training, Elisa H. Barney Smith, Tim Andersen
Text Degradations And Ocr Training, Elisa H. Barney Smith, Tim Andersen
Electrical and Computer Engineering Faculty Publications and Presentations
Printing and scanning of text documents introduces degradations to the characters which can be modeled. Interestingly, certain combinations of the parameters that govern the degradations introduced by the printing and scanning process affect characters in such a way that the degraded characters have a similar appearance, while other degradations leave the characters with an appearance that is very different. It is well known that (generally speaking) a test set that more closely matches a training set will be recognized with higher accuracy than one that matches the training set less well. Likewise, classifiers tend to perform better on data sets …