Computer Engineering Commons^™

Maprepeat: An Approach For Effective Assembly Of Repetitive Regions In Prokaryotic Genomes, Diego Cb Mariano, Felipe L. Pereira, Preetam Ghosh, Debmalya Barh, Henrique Cp Figueiredo, Artur Silva, Rommel Tj Ramos, Vasco Ac Azevedo

Computer Science Publications

The newest technologies for DNA sequencing have led to the determination of the primary structure of the genomes of organisms, mainly prokaryotes, with high efficiency and at lower costs. However, the presence of regions with repetitive sequences, in addition to the short reads produced by the Next-Generation Sequencing (NGS) platforms, created a lot of difficulty in reconstructing the original genome in silico. Thus, even today, genome assembly continues to be one of the major challenges in bioinformatics specifically when repetitive sequences are considered. In this paper, we present an approach to assemble repetitive regions in prokaryotic genomes. Our methodology …