Computer Engineering Commons^™

Wisdom Of Artificial Crowds Feature Selection In Untargeted Metabolomics: An Application To The Development Of A Blood-Based Diagnostic Test For Thrombotic Myocardial Infarction, Patrick J. Trainor, Roman V. Yampolskiy, Andrew P. Defilippis

Faculty Scholarship

Introduction: Heart disease remains a leading cause of global mortality. While acute myocardial infarction (colloquially: heart attack), has multiple proximate causes, proximate etiology cannot be determined by a blood-based diagnostic test. We enrolled a suitable patient cohort and conducted a non-targeted quantification of plasma metabolites by mass spectrometry for developing a test that can differentiate between thrombotic MI, non-thrombotic MI, and stable disease. A significant challenge in developing such a diagnostic test is solving the NP-hard problem of feature selection for constructing an optimal statistical classifier. Objective: We employed a Wisdom of Artificial Crowds (WoAC) strategy for solving the feature …