Computer Engineering Commons^™

Identifying Influential Nodes In A Wound Healing-Related Network Of Biological Processes Using Mean First-Passage Time, Tomasz Jakub Arodz, Danail Bonchev

Computer Science Publications

In this study we offer an approach to network physiology, which proceeds from transcriptomic data and uses gene ontology analysis to identify the biological processes most enriched in several critical time points of wound healing process (days 0, 3 and 7). The top-ranking differentially expressed genes for each process were used to build two networks: one with all proteins regulating the transcription of selected genes, and a second one involving the proteins from the signaling pathways that activate the transcription factors. The information from these networks is used to build a network of the most enriched processes with undirected links …