Computer Engineering Commons^™

Fdetect Webserver: Fast Predictor Of Propensity For Protein Production, Purification, And Crystallization, Fanchi Meng, Chen Wang, Lukasz Kurgan

Computer Science Publications

Background: Development of predictors of propensity of protein sequences for successful crystallization has been actively pursued for over a decade. A few novel methods that expanded the scope of these predictions to address additional steps of protein production and structure determination pipelines were released in recent years. The predictive performance of the current methods is modest. This is because the only input that they use is the protein sequence and since the experimental annotations of these data might be inconsistent given that they were collected across many laboratories and centers. However, even these modest levels of predictive quality are still …