Computer Engineering Commons^™

Pre-Training Graph Neural Networks For Link Prediction In Biomedical Networks, Yahui Long, Min Wu, Yong Liu, Yuan Fang, Chee Kong Kwoh, Jiawei Luo, Xiaoli Li

Research Collection School Of Computing and Information Systems

Motivation: Graphs or networks are widely utilized to model the interactions between different entities (e.g., proteins, drugs, etc) for biomedical applications. Predicting potential links in biomedical networks is important for understanding the pathological mechanisms of various complex human diseases, as well as screening compound targets for drug discovery. Graph neural networks (GNNs) have been designed for link prediction in various biomedical networks, which rely on the node features extracted from different data sources, e.g., sequence, structure and network data. However, it is challenging to effectively integrate these data sources and automatically extract features for different link prediction tasks. Results: In …