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Full-Text Articles in Computer Engineering
The Association Between Ambient Uvb Dose And Anca‑Associated Vasculitis Relapse And Onset, Jennifer Scott, Enock Havyarimana, Albert Navarro-Gallinad, Arthur White, Jason Wyse, Jos Van Geffen, Michiel Van Weele, Antonia Buettner, Tamara Wanigasekera, Cathal Walsh, Louis Aslett, John Kelleher, Julie Power, James Ng, Declan O’Sullivan, Lucy Hederman, Neil Basu, Mark A. Little, Lina Zgaga
The Association Between Ambient Uvb Dose And Anca‑Associated Vasculitis Relapse And Onset, Jennifer Scott, Enock Havyarimana, Albert Navarro-Gallinad, Arthur White, Jason Wyse, Jos Van Geffen, Michiel Van Weele, Antonia Buettner, Tamara Wanigasekera, Cathal Walsh, Louis Aslett, John Kelleher, Julie Power, James Ng, Declan O’Sullivan, Lucy Hederman, Neil Basu, Mark A. Little, Lina Zgaga
Articles
The aetiology of ANCA-associated vasculitis (AAV) and triggers of relapse are poorly understood. Vitamin D (vitD) is an important immunomodulator, potentially responsible for the observed latitudinal differences between granulomatous and non-granulomatous AAV phenotypes. A narrow ultraviolet B spectrum induces vitD synthesis (vitD-UVB) via the skin. We hypothesised that prolonged periods of low ambient UVB (and by extension vitD deficiency) are associated with the granulomatous form of the disease and an increased risk of AAV relapse.