Computer Engineering Commons^™

Decreased Home Cage Movement And Oromotor Impairments In Adult Fmr1-Ko Mice, Stephen J. Bonasera, Tammy R. Chaudoin, Evan H. Goulding, Mateusz Mittek, Anna Dunaevsky

Department of Electrical and Computer Engineering: Faculty Publications

Fragile X syndrome (FXS) is a common inherited disorder that significantly impacts family and patient day-to-day living across the entire lifespan. The childhood and adolescent behavioral consequences of FXS are well-appreciated. However, there are significantly fewer studies (except those examining psychiatric comorbidities) assessing behavioral phenotypes seen in adults with FXS. Mice engineered with a genetic lesion of Fmr1 recapitulate important molecular and neuroanatomical characteristics of FXS, and provide a means to evaluate adult behavioral phenotypes associated with FXS. We give the first description of baseline behaviors including feeding, drinking, movement, and their circadian rhythms; all observed over 16 consecutive days …