Computer Engineering Commons^™

Using An Integrative Machine Learning Approach To Study Microrna Regulation Networks In Pancreatic Cancer Progression, Roland Madadjim

Department of Computer Science and Engineering: Dissertations, Theses, and Student Research

With advances in genomic discovery tools, recent biomedical research has produced a massive amount of genomic data on post-transcriptional regulations related to various transcript factors, microRNAs, lncRNAs, epigenetic modifications, and genetic variations. In this direction, the field of gene regulation network inference is created and aims to understand the interactome regulations between these molecules (e.g., gene-gene, miRNA-gene) that take place to build models able to capture behavioral changes in biological systems. A question of interest arises in integrating such molecules to build a network while treating each specie in its uniqueness. Given the dynamic changes of interactome in chaotic systems …

Improving Backup And Restore Performance For Deduplication-Based Cloud Backup Services, Stephen Mkandawire

Department of Computer Science and Engineering: Dissertations, Theses, and Student Research

The benefits provided by cloud computing and the space savings offered by data deduplication make it attractive to host data storage services like backup in the cloud. Data deduplication relies on comparing fingerprints of data chunks, and store them in the chunk index, to identify and remove redundant data, with an ultimate goal of saving storage space and network bandwidth.

However, the chunk index presents a bottleneck to the throughput of the backup operation. While several solutions to address deduplication throughput have been proposed, the chunk index is still a centralized resource and limits the scalability of both storage capacity …