Chemical Engineering Commons^™

The Dependence Of The Overall Drying Time And Product Quality Of A Lyophilization Process On The Relative Position Of Vials On A Tray With Tray Sides And Without Tray Sides For Different Heat Input Control Policies, Kian Hui Gan

Masters Theses

"The dynamic behavior of the primary and secondary drying stages of the lyophilization process were studied when (a) single vials located at different positions on the tray were individually being dried, and (b) the vials on the tray are arranged in clusters of square and hexagonal arrays and all the vials on the tray are simultaneously being dried. For both cases (a) and (b), fast drying times and relatively more uniform distributions of temperature and concentration of bound water at the end of the secondary drying stage are obtained by heat input control that runs the lyophilization process close to …