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Transgenic Non-Human Mammals Expressing Human Coagulation Factor Viii And Von Willebrand Factor , William H. Velander
Transgenic Non-Human Mammals Expressing Human Coagulation Factor Viii And Von Willebrand Factor , William H. Velander
Department of Chemical and Biomolecular Engineering: Patents
A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human Factor VIII protein and a signal peptide, where the cis-acting regulatory units are active in mammary gland cells and the signal peptide is active in directing newly expressed Factor VIII into the milk of the animal. The promoter may be a milk protein promoter such as for whey acidic protein, casein, lactalbumin, or beta-lactoglobulin promoter. The transgenic mammals are preferably farm animals, for example, …
Transgenic Mammals Expressing Human Coagulation Factor Viii , William H. Velander
Transgenic Mammals Expressing Human Coagulation Factor Viii , William H. Velander
Department of Chemical and Biomolecular Engineering: Patents
A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human Factor VIII protein and a signal peptide, where the cis-acting regulatory units are active in mammary gland cells and the signal peptide is active in directing newly expressed Factor VIII into the milk of the animal. The promoter may be a milk protein promoter such as for whey acidic protein, casein, lactalbumin, or beta-lactoglobulin promoter. The transgenic mammals are preferably farm animals, for example, …