Chemical Engineering Commons^™

Chromatographic Separation Apparatus, Lynn S. Penn, Donna L. Scott, Howard H. Weetall, Anne L. Plant, Marion F. Mccurley, Scott A. Glazier

Chemical and Materials Engineering Faculty Patents

An apparatus for the monitoring of a column chromatography separation process includes a segmented column with a seal positioned at the joint defined by the segments of the column. A connector is provided for connecting the segments of the column together. The apparatus further includes a sensor for monitoring an analyte in an eluant within a separation zone of the column. The sensor includes a mesh grid made of optical fibers or metal wires which is placed so as to extend through the separation zone of the column. The metal wires or optical fibers extend through the seal of the …