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Full-Text Articles in Bioimaging and Biomedical Optics
Assessment Of White Matter Hyperintensity, Cerebral Blood Flow, And Cerebral Oxygenation In Older Subjects Stratified By Cerebrovascular Risk, Ahmed A. Bahrani
Assessment Of White Matter Hyperintensity, Cerebral Blood Flow, And Cerebral Oxygenation In Older Subjects Stratified By Cerebrovascular Risk, Ahmed A. Bahrani
Theses and Dissertations--Biomedical Engineering
Objective: Cerebrovascular disease (CVD) is the fifth most common cause of mortality in the United States. Diagnosis of CVD at an early stage is critical for optimal intervention designed to prevent ongoing and future brain injury. CVD is commonly associated with abnormalities of the cerebral microvasculature leading to tissue dysfunction, neuronal injury and death, and resultant clinical symptoms, which in turn, further impacts cerebral autoregulation (CA). This series of studies aims to test the hypothesis that white matter hyperintensities (WMH) and cerebral hemodynamics (quantified by magnetic resonance imaging (MRI) and an by innovative hybrid near-infrared diffuse optical instrument) can be …