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Full-Text Articles in Bioimaging and Biomedical Optics
Frequency Dependent Diffusion Kurtosis Measurement In The Human Brain With Oscillating Gradients, Kevin B. Borsos
Frequency Dependent Diffusion Kurtosis Measurement In The Human Brain With Oscillating Gradients, Kevin B. Borsos
Electronic Thesis and Dissertation Repository
Oscillating gradient spin-echo (OGSE) is an implementation of diffusion MRI that enables shorter effective diffusion times than the conventional pulse gradient spin-echo (PGSE) by periodically modulating the diffusion gradient. Measurements of the diffusion kurtosis, which reflects the degree of restricted diffusion, have previously been prohibited with OGSE due to technical limitations of clinical gradient systems. This thesis presents a novel oscillating gradient waveform that enables the measurement of kurtosis using OGSE without requiring advanced gradient hardware. Decreases of kurtosis are observed in OGSE acquisitions of healthy human subjects relative to PGSE, demonstrating the dependence of the kurtosis on oscillation frequency. …
Development Of Quantitative Molecular Photoacoustic Imaging For Noninvasive Cancer Diagnostics, Cayla Zandbergen
Development Of Quantitative Molecular Photoacoustic Imaging For Noninvasive Cancer Diagnostics, Cayla Zandbergen
Dissertations & Theses (Open Access)
Traditional diagnostic imaging provides clinicians with anatomical information that guides both diagnosis and treatment planning; however, once a tumor has progressed enough to be visible, it has often reached an advanced stage. Molecular imaging techniques allow for real-time visualization of chemical and biological processes via imaging of specific biomarkers, which can facilitate detection of malignancies before they become visible. One biomarker of interest is blood oxygen saturation (SO2) due to its correlation with hypoxia, which is associated with increased tumor malignancy; some studies have also established SO2 as an independent biomarker of disease progression. Additionally, because cancerous …