Biomedical Engineering and Bioengineering Commons^™

Modeling And Experimental Methods To Predict Oxygen Distribution In Bone Defects Following Cell Transplantation, Christopher M. Heylman, Sharon Santoso, Melissa D. Krebs, Gerald M. Saidel, Eben Alsberg, George F. Muschler

Biomedical Engineering

We have developed a mathematical model that allows simulation of oxygen distribution in a bone defect as a tool to explore the likely effects of local changes in cell concentration, defect size or geometry, local oxygen delivery with oxygen-generating biomaterials (OGBs), and changes in the rate of oxygen consumption by cells within a defect. Experimental data for the oxygen release rate from an OGB and the oxygen consumption rate of a transplanted cell population are incorporated into the model. With these data, model simulations allow prediction of spatiotemporal oxygen concentration within a given defect and the sensitivity of oxygen tension …