Biomedical Engineering and Bioengineering Commons^™

Regulation Of Bone Marrow Stem Cells Through Oscillatory Shear Stresses - A Heart Valve Tissue Engineering Perspective, Sasmita Rath

FIU Electronic Theses and Dissertations

Heart valve disease occurs in adults as well as in pediatric population due to age-related changes, rheumatic fever, infection or congenital condition. Current treatment options are limited to mechanical heart valve (MHV) or bio-prosthetic heart valve (BHV) replacements. Lifelong anti-coagulant medication in case of MHV and calcification, durability in case of BHV are major setbacks for both treatments. Lack of somatic growth of these implants require multiple surgical interventions in case of pediatric patients. Advent of stem cell research and regenerative therapy propose an alternative and potential tissue engineered heart valves (TEHV) treatment approach to treat this life threatening condition. …