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Full-Text Articles in Biomedical Engineering and Bioengineering
High Frequency Oscillations In The Epileptic Brain: Accurate Detection, Effect Of Vigilance State, And Sample Size Considerations, Amir Fared Partu Al-Bakri
High Frequency Oscillations In The Epileptic Brain: Accurate Detection, Effect Of Vigilance State, And Sample Size Considerations, Amir Fared Partu Al-Bakri
Theses and Dissertations--Biomedical Engineering
About a third of all epilepsy patients may experience seizures that are resistant to medication. Surgical resection may be an option for some of these patients, but localization of the epileptogenic zone is difficult and expensive. For this process, the seizures must be observed and recorded in a clinical setting over several days. High-frequency oscillations (HFOs) have emerged as a possible biomarker for predicting the epileptogenic zone from a brief interictal recording of brain electrical activity without having to wait for seizures. The broad objective of this dissertation is to devise methods and criteria for accurate detection, sampling and localization …
Sleep And Thermoregulation: A Study Of The Effect Of Ambient Temperature Manipulation On Mouse Sleep Architecture, Asma'a A. Ajwad
Sleep And Thermoregulation: A Study Of The Effect Of Ambient Temperature Manipulation On Mouse Sleep Architecture, Asma'a A. Ajwad
Theses and Dissertations--Biomedical Engineering
Good quality sleep is essential for mental and physical health. Inadequate sleep impacts memory consolidation, learning and cognition, immune function, autonomic regulation, physical performance, and other vital functions. In many neurological disorders that are associated with sleep problems such as epilepsy and Alzheimer’s disease, changes in brain circuitry affect sleep-wake regulation mechanisms; this is reflected in anomalous sleep-wake architecture and usually accompanied by poor sleep depth. Thus, over many years, many approaches have been tried in humans and animal models with the goal of improving sleep quality. Unfortunately, each of those approaches comes with limitations or side effects. Thus, there …
Experimental-Computational Analysis Of Vigilance Dynamics For Applications In Sleep And Epilepsy, Farid Yaghouby
Experimental-Computational Analysis Of Vigilance Dynamics For Applications In Sleep And Epilepsy, Farid Yaghouby
Theses and Dissertations--Biomedical Engineering
Epilepsy is a neurological disorder characterized by recurrent seizures. Sleep problems can cooccur with epilepsy, and adversely affect seizure diagnosis and treatment. In fact, the relationship between sleep and seizures in individuals with epilepsy is a complex one. Seizures disturb sleep and sleep deprivation aggravates seizures. Antiepileptic drugs may also impair sleep quality at the cost of controlling seizures. In general, particular vigilance states may inhibit or facilitate seizure generation, and changes in vigilance state can affect the predictability of seizures. A clear understanding of sleep-seizure interactions will therefore benefit epilepsy care providers and improve quality of life in patients. …