Biomedical Engineering and Bioengineering Commons^™

Alterations In Wall Shear Stress Predict Sites Of Neointimal Hyperplasia After Stent Implantation In Rabbit Iliac Arteries, John F. Ladisa, Lars E. Olson, Robert C. Molthen, Douglas Anthony Hettrick, Phillip F. Pratt, Michael D. Hardel, Judy R. Kersten, David C. Warltier, Paul S. Pagel

Biomedical Engineering Faculty Research and Publications

Restenosis resulting from neointimal hyperplasia (NH) limits the effectiveness of intravascular stents. Rates of restenosis vary with stent geometry, but whether stents affect spatial and temporal distributions of wall shear stress (WSS) in vivo is unknown. We tested the hypothesis that alterations in spatial WSS after stent implantation predict sites of NH in rabbit iliac arteries. Antegrade iliac artery stent implantation was performed under angiography, and blood flow was measured before casting 14 or 21 days after implantation. Iliac artery blood flow domains were obtained from three-dimensional microfocal X-ray computed tomography imaging and reconstruction of the arterial casts. Indexes of …