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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Hypothesis Paper: Mechanism For Primary Blast Induced Traumatic Brain Injury With Minimal Head Motion, Charles F. Babbs
Hypothesis Paper: Mechanism For Primary Blast Induced Traumatic Brain Injury With Minimal Head Motion, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Working Papers
Transit of the human skull by blast waves produces diffuse brain injury. The exact mechanisms are unknown. This paper describes plausible mechanisms in which steep intracranial pressure gradients, demonstrated in prior computational models of blast-skull interaction, produce subsequent deformation and motion of the whole brain within the skull, without obvious movement of the head. Equations of motion are derived to describe the acceleration, velocity, and relative position of both the skull and the brain in response to known extracranial and intracranial pressures both during and several hundred milliseconds after blast wave passage. A finite element model is solved to visualize …
Characterization And Quantification Of Fibrin Gel Mechanics With Fibroblast Invasion, Nicklaus Iavagnilio, Sarah Calve, Adrian Buganza-Tepole
Characterization And Quantification Of Fibrin Gel Mechanics With Fibroblast Invasion, Nicklaus Iavagnilio, Sarah Calve, Adrian Buganza-Tepole
The Summer Undergraduate Research Fellowship (SURF) Symposium
Cutaneous wounds undergo an intricate healing process stimulated by a variety of local mechanical and biological stimuli that lead to patterns of growth and remodeling. Despite significant research in dermal wound healing, pathological scarring is still common particularly in wounds closed under mechanical stress, or large wounds left to heal by secondary intention. The purpose of this study is to utilize previously established wound healing models using fibrin gels and fibroblasts to better understand the functional relationships of the biological processes of normal compared to abnormal wound healing. Increases in uni-axial strain and transforming growth factor beta-1 concentration have been …