Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Biomedical Engineering and Bioengineering
Uc2288 Improves Osteogenic Capacity Of Murine Mesenchymal Stem Cells, Alisha Shaikh
Uc2288 Improves Osteogenic Capacity Of Murine Mesenchymal Stem Cells, Alisha Shaikh
Theses and Dissertations
The role of p21 is crucial in the cell cycle as it plays a diverse role in regulating it. Studies have demonstrated its role in proliferation, differentiation, apoptosis, and senescence. Inhibition of p21 has been shown to improve bone healing and regeneration after injury. UC2288 a cell-permeable molecule has been shown to inhibit p21. In this project we aim to assess the osteogenic capacity of UC2288. We tested the cytotoxicity of UC2288 with murine MSCs followed by culturing MSCs with UC2288 to test its capacity to differentiate into osteoblasts. Our results indicate that UC2288 increases MSC differentiation into osteoblasts as …
Controlled Codelivery Of Mir-26a And Antagomir-133a With Osteoconductive Scaffolds To Promote Healing Of Large Bone Defects, Cole J. Ferreira
Controlled Codelivery Of Mir-26a And Antagomir-133a With Osteoconductive Scaffolds To Promote Healing Of Large Bone Defects, Cole J. Ferreira
Masters Theses
Often caused by trauma or tumor removal, large bone defects frequently result in delayed or non-union. The current gold standard for treatment is autograft. However, due to limitations, such as the size and location of the defect, these cannot always be utilized. A common alternative to autograft is the use of BMP-2 with a collagen scaffold, however, this treatment is limited by numerous side effects. In recent years, genetic materials such as microRNAs (miRNAs) have offered possible alternative therapies. MiRNAs are small non-coding RNA molecules that generally range from 20-24 nucleotides, serve as repressors of gene expression, and are involved …