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Biomedical Engineering and Bioengineering Commons™

Open Access. Powered by Scholars. Published by Universities.®

2022

Biomedical Engineering

Articles 1 - 6 of 6

Full-Text Articles in Biomedical Engineering and Bioengineering

An Improved Polynomial Chaos Expansion Based Response Surface Method And Its Applications On Frame And Spring Engineering Based Structures, Mhd A. Hafez Jun 2022

An Improved Polynomial Chaos Expansion Based Response Surface Method And Its Applications On Frame And Spring Engineering Based Structures, Mhd A. Hafez

ETD Archive

In engineering fields, computational models provide a tool that can simulate a real world response and enhance our understanding of physical phenomenas. However, such models are often computationally expensive with multiple sources of uncertainty related to the model’s input/assumptions. For example, the literature indicates that ligament’s material properties and its insertion site locations have a significant effect on the performance of knee joint models, which makes addressing uncertainty related to them a crucial step to make the computational model more representative of reality. However, previous sensitivity studies were limited due to the computational expense of the models. The high computational …

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Developing New Crutch Tip Design For Overall Increased Stability And Improved Movement On Different Terrains, Lauren Skinner May 2022

Developing New Crutch Tip Design For Overall Increased Stability And Improved Movement On Different Terrains, Lauren Skinner

Honors Theses

Crutches are a mobility assistive device that are often used in various situations, such as post- surgical rehabilitation and recovery after injury. The current crutch tip design that is used on today’s crutches are often unstable and do not provide quality movement on different terrains, such as snow, ice, mud, and wet surfaces. These problems would be solved with a new tip design that could be attached to existing crutches or manufactured with the crutch itself. The team’s solution to this problem is a crutch tip with modular parts. The tip would attach to the shaft of the crutch like …

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Disparities In Response, Motivations, And Self-Efficacy To Entrepreneurially Minded Learning Within Underrepresented Students' Groups, Kaitlin Hall May 2022

Disparities In Response, Motivations, And Self-Efficacy To Entrepreneurially Minded Learning Within Underrepresented Students' Groups, Kaitlin Hall

Biomedical Engineering Undergraduate Honors Theses

Systemic racism in the United States is embedded within the policies that have created oppression for certain groups. Women, people of color, and those from low-income families have less access to entrepreneurial knowledge due to the education gap. It has been determined that less than 20 percent of US patents entail a female inventor. Black and Hispanic college graduates also lack this access as fewer than half as many individuals hold patents. Ensuring that these populations are educated in inventor knowledge can facilitate greater inclusion. The historical Brown vs the Board of Education intended to end unequal public schooling. It …

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Neural Processing Of Semantic Content In Movies, Maximilian Nentwich Jan 2022

Neural Processing Of Semantic Content In Movies, Maximilian Nentwich

Dissertations and Theses

Naturalistic stimuli, such as movies, contain interacting, multimodal and semantic features and allow for free exploration through eye movements. The full extent of neural responses to features such as motion, film cuts and eye movement behavior has not been established. The main hypothesis of this thesis is that complex multimodal and semantic stimuli in naturalistic movies engage a widespread ensemble of locations across the entire brain. To address this question I analyzed simultaneous intracranial and eyetracking data from over 6,000 electrodes across 23 patients with intractable epilepsy. Responses to fast eye movements – saccades – and film cuts are widespread …

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Exploring Cell Differentiation Vs. Localization In Engineered Ligament-To-Bone Entheses, Saagar N. Sheth, Michael E. Brown, Jennifer L. Puetzer Jan 2022

Exploring Cell Differentiation Vs. Localization In Engineered Ligament-To-Bone Entheses, Saagar N. Sheth, Michael E. Brown, Jennifer L. Puetzer

Undergraduate Research Posters

The anterior cruciate ligament (ACL) connects to bone via structurally complex insertions known as entheses that translate load from elastic ligament and stiff bone via gradients in organization, composition, and cell phenotype [1]. These gradients are not recreated in graft repair or engineered replacements, yielding limited repair options and high failure rates [2]. Previously, we developed a culture system that uses a tensile-compressive interface to guide ligament fibroblasts to develop early postnatal-like entheses by 6 weeks [3]; however, cells used were isolated from the entirety of the neonatal bovine ACL from bone to bone and likely contained multiple cell phenotypes …

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Development Of Gene Regulatory Elements For Biosensing Applications, Mallory N. Bates Jan 2022

Development Of Gene Regulatory Elements For Biosensing Applications, Mallory N. Bates

Browse all Theses and Dissertations

21% of U.S adults experienced mental illnesses in 2020. Nearly 1 in 4 active- duty military personnel showed signs of mental health conditions in 2014 [89]. Mental health can be identified in the body by different biomarkers. These biomarkers potentially could be controlled by riboswitches, which could help mental illnesses and regulate diseases. Riboswitches are desirable in these cases due to responding without affecting vital functions. Riboswitches are located in mRNA and switch “ON” or “OFF” depending on the concentration of a biomarker [13]. In this research, riboswitches were re-engineered to take a known riboswitch and control its response in …

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