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Full-Text Articles in Biomedical Engineering and Bioengineering
A Computational Framework To Model Mesenchymal Stem Cell Nucleus Mechanics Using Confocal Microscopy, Zeke Kennedy
A Computational Framework To Model Mesenchymal Stem Cell Nucleus Mechanics Using Confocal Microscopy, Zeke Kennedy
Boise State University Theses and Dissertations
The mechanical properties of the cell nucleus are emerging as a key component in genetic transcription. It has been shown that the stiffness of the nucleus in part regulates the transcription of genes in response to external mechanical stimuli. The stiffness has been shown to change as a result of both disease and changes to the external environment. While the mechanical structure of the nucleus can be visually documented using a confocal microscope, it is currently impossible to test the stiffness of the nucleus without a mechanical testing apparatus such as an atomic force microscope. This is problematic in that …
Computational Approach To Correcting Joint Instability In Patients With Recurrent Patellar Dislocation, Oliver Alvarez, Robert N. Steensen, Paul J. Rullkoetter, Clare K. Fitzpatrick
Computational Approach To Correcting Joint Instability In Patients With Recurrent Patellar Dislocation, Oliver Alvarez, Robert N. Steensen, Paul J. Rullkoetter, Clare K. Fitzpatrick
Mechanical and Biomedical Engineering Faculty Publications and Presentations
Patellar dislocation is a debilitating injury common in active adolescents and young adults. Conservative treatment after initial dislocation is often recommended, but almost half of these patients continue to suffer from recurrent dislocation. The objective of this study was to compare preoperative patellofemoral joint stability with stability after a series of simulated procedures, including restorative surgery to correct to pre-injury state, generic tibial tubercle osteotomy, patient-specific reconstructive surgery to correct anatomic abnormality, less invasive patient-specific surgery, and equivalent healthy controls. Three-dimensional, subject-specific finite element models of the patellofemoral joint were developed for 28 patients with recurrent patellar dislocation. A …
Biomechanical Behavior Of A Variable Angle Locked Tibiotalocalcaneal Construct, Farah Hamandi, Gerard Simon, Richard T. Laughlin, Tarun Goswami
Biomechanical Behavior Of A Variable Angle Locked Tibiotalocalcaneal Construct, Farah Hamandi, Gerard Simon, Richard T. Laughlin, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
This paper examines the mechanics of the tibiotalocalcaneal construct made with a PHILOS plating system. A failed device consisting of the LCP plate and cortical, locking, and cannulated screws was used to perform the analysis. Visual, microstructure, and fractographic examinations were carried out to characterize the fracture surface topology. These examinations revealed the presence of surface scratching, inclusions, discoloration, corrosion pits, beach marks, and cleavage and striations on the fracture surface. Further examination of the material crystallography and texture revealed an interaction of S, Ni, and Mo-based inclusions that may have raised pitting susceptibility of the device made with Stainless …