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Biomedical Engineering and Bioengineering Commons™
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- Bioprinting; Data science; Tissue engineering; Computer vision; Nerve regeneration; Machine learning; Artificial intelligence; ACCELERATES AXON REGENERATION; PERIPHERAL-NERVE; SCHWANN-CELLS; ELECTRICAL-STIMULATION; GROWTH-FACTOR; GENE-THERAPY; NEUROTROPHIC FACTOR; GUIDANCE CHANNELS; NEURAL-NETWORK; SCIATIC-NERVE (1)
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Articles 1 - 6 of 6
Full-Text Articles in Biomedical Engineering and Bioengineering
3-D Fabry–Pérot Cavities Sculpted On Fiber Tips Using A Multiphoton Polymerization Process, Jonathan W. Smith, Jeremiah C. Williams, Joseph S. Suelzer, Nicholas G. Usechak, Hengky Chandrahalim
3-D Fabry–Pérot Cavities Sculpted On Fiber Tips Using A Multiphoton Polymerization Process, Jonathan W. Smith, Jeremiah C. Williams, Joseph S. Suelzer, Nicholas G. Usechak, Hengky Chandrahalim
Faculty Publications
This paper presents 3-D Fabry–Pérot (FP) cavities fabricated directly onto cleaved ends of low-loss optical fibers by a two-photon polymerization (2PP) process. This fabrication technique is quick, simple, and inexpensive compared to planar microfabrication processes, which enables rapid prototyping and the ability to adapt to new requirements. These devices also utilize true 3-D design freedom, facilitating the realization of microscale optical elements with challenging geometries. Three different device types were fabricated and evaluated: an unreleased single-cavity device, a released dual-cavity device, and a released hemispherical mirror dual-cavity device. Each iteration improved the quality of the FP cavity's reflection spectrum. The …
Machine Intelligence For Nerve Conduit Design And Production, Caleb E. Stewart, Chin Fung Kelvin Kan, Brody R. Stewart, Henry W. Sanicola Iii, Jangwook P. Jung, Olawale A. R. Sulaiman, Dadong Wang
Machine Intelligence For Nerve Conduit Design And Production, Caleb E. Stewart, Chin Fung Kelvin Kan, Brody R. Stewart, Henry W. Sanicola Iii, Jangwook P. Jung, Olawale A. R. Sulaiman, Dadong Wang
Faculty Publications
Nerve guidance conduits (NGCs) have emerged from recent advances within tissue engineering as a promising alternative to autografts for peripheral nerve repair. NGCs are tubular structures with engineered biomaterials, which guide axonal regeneration from the injured proximal nerve to the distal stump. NGC design can synergistically combine multiple properties to enhance proliferation of stem and neuronal cells, improve nerve migration, attenuate inflammation and reduce scar tissue formation. The aim of most laboratories fabricating NGCs is the development of an automated process that incorporates patient-specific features and complex tissue blueprints (e.g. neurovascular conduit) that serve as the basis for more complicated …
Thermoresponsive Nanogels Based On Different Polymeric Moieties For Biomedical Applications, Sobhan Ghaeini-Hesaroeiye, Hossein Razmi Bagtash, Soheil Boddohi, Ebrahim Vasheghani-Farahani, Esmaiel Jabbari
Thermoresponsive Nanogels Based On Different Polymeric Moieties For Biomedical Applications, Sobhan Ghaeini-Hesaroeiye, Hossein Razmi Bagtash, Soheil Boddohi, Ebrahim Vasheghani-Farahani, Esmaiel Jabbari
Faculty Publications
Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing amide groups, ether groups, vinyl ether groups and hydrophilic polymers bearing hydrophobic groups. These novel thermoresponsive nanogels …
Thermoresponsive Nanogels Based On Different Polymeric Moieties For Biomedical Applications, Sobhan Ghaeini-Hesaroeiye, Hossein Razmi Bagtash, Soheil Boddohi, Ebrahim Vasheghani-Farahani, Esmaiel Jabbari
Thermoresponsive Nanogels Based On Different Polymeric Moieties For Biomedical Applications, Sobhan Ghaeini-Hesaroeiye, Hossein Razmi Bagtash, Soheil Boddohi, Ebrahim Vasheghani-Farahani, Esmaiel Jabbari
Faculty Publications
Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing amide groups, ether groups, vinyl ether groups and hydrophilic polymers bearing hydrophobic groups. These novel thermoresponsive nanogels …
Carbon-Based Artificial Sei Layers For Aqueous Lithium-Ion Battery Anodes, Usha Subramanya, Charleston Chua, Victor Gin He Leong, Ryan Robinson, Gwenlyn Cruz Cabiltes, Prakirti Singh, Bonnie Yip, Anuja Bokare, Folarin Erogbogbo, Dahyun Oh
Carbon-Based Artificial Sei Layers For Aqueous Lithium-Ion Battery Anodes, Usha Subramanya, Charleston Chua, Victor Gin He Leong, Ryan Robinson, Gwenlyn Cruz Cabiltes, Prakirti Singh, Bonnie Yip, Anuja Bokare, Folarin Erogbogbo, Dahyun Oh
Faculty Publications
Replacing flammable organic electrolytes with aqueous electrolytes in lithium-ion batteries (LIB) can greatly enhance the safety of next-generation energy storage systems. With the extended electrochemical stability window of electrolytes, 'water-in-salt' (WIS) electrolytes containing LIB presented significant performance improvements. However, the solubility limits of lithium salts in water restrain the extent of kinetic protection offered by the high salt concentration. Here, we report design strategies of anode structure to improve the cycle life of LIB with WIS electrolytes. We introduced partially graphitic protective carbon layers on anode particles using a versatile coating method. This protective layer not only improved charge transfer …
Analysis Of Yarrowia Lipolytica Growth, Catabolism, And Terpenoid Biosynthesis During Utilization Of Lipid-Derived Feedstock, Alyssa M. Worland, Jeffrey J. Czajka, Yun Xing, Willie F. Harper Jr., Aryiana Moore, Zhengyang Xiao, Zhenlin Han, Yechun Wang, Wei Wen Su, Yinjie J. Tang
Analysis Of Yarrowia Lipolytica Growth, Catabolism, And Terpenoid Biosynthesis During Utilization Of Lipid-Derived Feedstock, Alyssa M. Worland, Jeffrey J. Czajka, Yun Xing, Willie F. Harper Jr., Aryiana Moore, Zhengyang Xiao, Zhenlin Han, Yechun Wang, Wei Wen Su, Yinjie J. Tang
Faculty Publications
This study employs biomass growth analyses and 13C-isotope tracing to investigate lipid feedstock utilization by Yarrowia lipolytica. Compared to glucose, oil-feedstock in the minimal medium increases the yeast's biomass yields and cell sizes, but decreases its protein content (<20% of total biomass) and enzyme abundances for product synthesis. Labeling results indicate a segregated metabolic network (the glycolysis vs. the TCA cycle) during co-catabolism of sugars (glucose or glycerol) with fatty acid substrates, which facilitates resource allocations for biosynthesis without catabolite repressions. This study has also examined the performance of a β-carotene producing strain in different growth mediums. Canola oil-containing yeast-peptone (YP) has resulted in the best β-carotene titer (121 ± 13 mg/L), two-fold higher than the glucose based YP medium. These results highlight the potential of Y. lipolytica for the valorization of waste-derived lipid feedstock.