Biomedical Engineering and Bioengineering Commons^™

Bioengineering Extracellular Matrix Scaffolds For Volumetric Muscle Loss, Kevin Roberts

Graduate Theses and Dissertations

Volumetric muscle loss overwhelms skeletal muscle’s ordinarily capable regenerative machinery, resulting in fibrosis and severe functional deficits which have defied clinical repair strategies. My work spans the design and preclinical evaluation of implants intended to drive the cell community of injured muscle toward a regenerative state, as well as the development of an understanding of the molecular responses of this cell community to biomaterial interventions. I demonstrate a new class of biomaterial by leveraging the productive capacity of sacrificial hollow fiber membrane cell culture; I show specifically that unique threads of whole extracellular matrix can be isolated by solvent degradation …

Development Of Investment Casting Method For Production Of Metal Foams For Tissue Engineering, Justin Aaron Womack

Theses and Dissertations

Ideal biomaterials for bone tissue regeneration are bone-mimicking structures that present a fully interconnected porous structure, have similar mechanical properties to bone, and exhibits a specific biodegradation behavior that is at the same rate as adjoining cell growth. Metals have high wear resistance, ductility, impact strength, and strain energy absorption capacity compared to other materials, which makes them suitable candidates for tissue engineering scaffolds. Magnesium and zinc are of interest for bone tissue regeneration for their biocompatibility and mechanical properties close to human bone. A newly developed process, presented in this thesis, for the creation of porous magnesium and zinc …

Pressure Cylinder Controlled Release Valve, Alexa Dominique Balbuena

Biomedical Engineering

This project aims to integrate an automatic gas release system in a pre-existing scaffold fabrication process for tissue engineering applications.

To form the proper scaffold structure, the fabrication process is heavily influenced by the change in its surrounding pressure. The current production involves a pressure transducer and electric valve that is managed manually to create a suitable pressure environment for the scaffold. This method, although functional, proves to be ineffective when creating several batches; the user needs to constantly monitor the developing pressure profile and alter voltage parameters accordingly to create a linear gas release under a predetermined slope.

To …