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Full-Text Articles in Biomedical Engineering and Bioengineering
Cerebro-Vascular Disruption Mediated Initiation And Propagation Of Traumatic Brain Injury In A Fluid Percussion Injury Model, Xiaotang Ma
Dissertations
Traumatic brain injury (TBI) is a major health problem for over 3.17 million people in the US. There is no FDA-approved drug for the treatment because the injury mechanisms have not been clearly identified. The knowledge gap is addressed here by the lateral fluid percussion injury (FPI) rat model, through the understanding of layer-structured mechanisms from physical vascular rupture to acute necrosis, as well as biochemical changes in perivascular space as secondary events.
Firstly, the cerebrovascular hemorrhage and related infarct volume are investigated as the primary events in moderate FPI, which is found to be increased with injury severity in …
Rage Expression And Inflammation In Alzheimer’S Disease: In Vitro Model Development And Investigation Of A Potential Peptoid Inhibitor, Lauren Michell Wolf
Rage Expression And Inflammation In Alzheimer’S Disease: In Vitro Model Development And Investigation Of A Potential Peptoid Inhibitor, Lauren Michell Wolf
Theses and Dissertations
Despite the increasing prevalence of Alzheimer’s disease (AD), efforts to establish a definitive treatment or cure have met with little success. Many previous therapeutic strategies for AD have focused on the aggregation and accumulation of amyloid-b (Ab) in the brain, concentrating on its small intermediate aggregates as the primary targets to ameliorate neurotoxicity and damage. This approach has yielded little progress, and more recent discussions have shifted to strategies geared toward a multifaceted pathology, with chronic neuroinflammation emerging as an important factor in the disease etiology and progression.
The receptor for advanced glycation end-products, or RAGE, is …