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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 5 of 5
Full-Text Articles in Biomedical Engineering and Bioengineering
Efficacy Of Eluted Antibiotics In 3d Printed Orthopaedic Implants, Mohammed Mehdi Benmassaoud
Efficacy Of Eluted Antibiotics In 3d Printed Orthopaedic Implants, Mohammed Mehdi Benmassaoud
Theses and Dissertations
Costs associated with musculoskeletal diseases in the United States account for 5.7 % of the Gross Domestic Product (GDP) [1]. As such, there is a need to pursue new ideas in orthopaedic implants that can decrease cost and improve patient care. In the recent years, 3D printing using Fused Deposition Modeling (FDM) or Stereolithography (SLA) has opened several exciting possibilities to create orthopaedic implants. Such implants can be engineered to release antibiotics in a controlled manner either by infusing the drug into the material during manufacturing or by using built-in design features such as micro-channels and reservoirs [2]. The use …
Kinematic Analysis Of Spinal Cord Injury Animals Treated With A Neurotrophin-Infused Scaffold And Body Weight Supported Treadmill Training, Alexander Herman
Kinematic Analysis Of Spinal Cord Injury Animals Treated With A Neurotrophin-Infused Scaffold And Body Weight Supported Treadmill Training, Alexander Herman
Theses and Dissertations
Spinal Cord Injury (SCI) is a condition that affects around 250,000 Americans with no cure. Existing treatments rely on physical therapies such as body weight support treadmill training (BWSTT). Treatments currently being researched include the use of implantable cells and biomaterials. Our study investigated the changes in locomotive gait and range of motion via a combinational treatment using a bioengineered scaffold [poly (N-isopropyl acrylamide) polyethylene glycol (PNIPAAm-g-PEG) with BDNF and NT-3] and rehabilitation training using BWSTT in a clinically relevant contusion SCI animal model. Five different groups of animals (Sham, Injury, BWSTT, Implant, and Combinational) were tested on a treadmill …
Thermal Fluid Models Of A Hydrogel Delivery System For Pancreatic Cancer Treatment, Nesrine Bouhrira
Thermal Fluid Models Of A Hydrogel Delivery System For Pancreatic Cancer Treatment, Nesrine Bouhrira
Theses and Dissertations
Pancreatic cancer is one of the most devastating cancers with low survival rates. This disease is difficult to detect due to the pancreas's location deep within the body. Therefore, diagnoses are often made in the later stages, making treatment options more limited and difficult. It has been hypothesized that direct injection into the tumor would enhance drug effectivenes. Therefore, we examined the use of endoscopic ultrasound (EUS) combined with a fine needle injection to deliver a drug-eluding thermosensitive hydrogel directly into the tumor. Unfortunately normal body temperatures surrounding the EUS can warm the hydrogel drug combination beyond its phase transition …
Fibers For Skin Regeneration, Astrid Michelle Rodriguez Negron
Fibers For Skin Regeneration, Astrid Michelle Rodriguez Negron
Theses and Dissertations
This thesis presents the successful development of biocompatible Polyvinyl Butyral (PVB), PVB/Polylysine and PVB/Tannic Acid (TA)/Polylysine fibers from an ethanol solution, Polyhydroxybutyrate (PHB), PHB/Polylysine, PHB/TA/Polylysine fibers from a chloroform solution and Chitosan (CH)/Pullulan (PL)/TA and CH/PL/TA/Polylysine fibers from an aqueous solution. The fibers were mass produced utilizing the Forcespinning® (FS) technology. The morphology of the fibers was characterized using a scanning electron microscope (SEM) and the fibers average diameter was calculated. The thermal properties of the fibers were characterized using a thermogravimetric analyzer (TGA) and a differential scanning calorimeter (DSC). The antibacterial activity of the fibers was assessed using against …
Development Of Novel Models To Study Deep Brain Effects Of Cortical Transcranial Magnetic Stimulation, Farheen Syeda
Development Of Novel Models To Study Deep Brain Effects Of Cortical Transcranial Magnetic Stimulation, Farheen Syeda
Theses and Dissertations
Neurological disorders require varying types and degrees of treatments depending on the symptoms and underlying causes of the disease. Patients suffering from medication-refractory symptoms often undergo further treatment in the form of brain stimulation, e.g. electroconvulsive therapy (ECT), transcranial direct current stimulation (tDCS), deep brain stimulation (DBS), or transcranial magnetic stimulation (TMS). These treatments are popular and have been shown to relieve various symptoms for patients with neurological conditions. However, the underlying effects of the stimulation, and subsequently the causes of symptom-relief, are not very well understood. In particular, TMS is a non-invasive brain stimulation therapy which uses time-varying magnetic …