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Full-Text Articles in Biomedical Engineering and Bioengineering
The Effect Of Tgfβ-1 On Adipose-Derived Stem Cell (Asc) Ring Constructs, Ashley C. Apil
The Effect Of Tgfβ-1 On Adipose-Derived Stem Cell (Asc) Ring Constructs, Ashley C. Apil
Research Opportunities for Engineering Undergraduates (ROEU) Program 2016-17
Adipose-derived Stem Cells (ASC’s) provide an optimal source for potentially graft replacing, tissue-engineered vessel constructs due to their ease of extraction and ability to be patient-specific. In order to make ASC ring constructs a more viable replacement for grafts, they need to have mechanical properties similar to native arteries, which is largely influenced by the extracellular matrix protein collagen. TGFβ-1 is known to stimulate collagen production in ASC’s, so this study explores the effect that TGFβ-1 has on the resulting thickness and tensile strength of ASC ring constructs.