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Biomimetic And Vascularized 3-D Liver Cancer Model, Derek Yip

Dissertations

Anti-angiogenic drugs have failed to show significant extended mortality, except when co-administered with chemotherapy drugs in clinical trials. This should be predicted by in vitro models, and yet 2D in vitro models of liver cancer co-administered with these two types of drugs show increased cell viability, contradicting clinical trials. In vitro models should mimic clinical trials in order to accurately predict drug outcomes. 2D in vitro models fail because they lack features of the cancer environment such as presence of stromal cells and a vasculature.

In order to achieve a biomimetic and vascularized in vitro model that would better recapitulate …