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Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- <p>Glass in medicine<br />Solid freeform fabrication<br />Tissue scaffolds<br />Bioactive compounds<br />Bone regeneration</p> (1)
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Articles 1 - 13 of 13
Full-Text Articles in Biomedical Engineering and Bioengineering
Removal Of Trace Organic Compounds In Domestic Wastewater Using Recirculating Packed-Bed Media Filters, Brittani Nikole Perez
Removal Of Trace Organic Compounds In Domestic Wastewater Using Recirculating Packed-Bed Media Filters, Brittani Nikole Perez
Masters Theses
Pharmaceuticals and personal care products (PPCPs) are commonly detected in the environment resulting from their survival from conventional wastewater treatment systems. More information is needed about the fate and transfer of these trace organic compounds in domestic wastewater and their associated risks so that efficient strategies for their removal can be developed for both large/small scale treatment systems. This study aimed to determine whether onsite wastewater treatment systems were capable of providing PPCP removal, in addition to quantifying different forms of removal (biodegradation/sorption). A column study was constructed to determine the removal efficiencies of 3 target PPCPs, endocrine disrupting compound …
Icloudecg: A Mobile Cardiac Telemedicine System, David S. Clifford
Icloudecg: A Mobile Cardiac Telemedicine System, David S. Clifford
Masters Theses
With rising healthcare costs and a substantially growing number of patients 65 or over, the benefits of telemedicine and patient self-monitoring systems are becoming increasingly evident. Patients, physicians, hospitals, and even insurance providers benefit from vigilant, cost-effective patient monitoring systems. This thesis describes the development of a portable, smart-phone connected system for continuous cardiac monitoring. The system is capable of continuously monitoring the conditions of the heart, automated detection of cardiac arrhythmias, and real-time notifying patients and physicians of the detected abnormalities. The system consists of four main subsystems: 1) a Bluetooth capable chest-strap ECG, 2) an Android-enabled mobile device, …
Effects Of Varus Knee Alignment And Using Toe-Cages On Frontal Plane Knee Biomechanics In Stationary Cycling, Guangping Shen
Effects Of Varus Knee Alignment And Using Toe-Cages On Frontal Plane Knee Biomechanics In Stationary Cycling, Guangping Shen
Masters Theses
Effects of varus knee alignment on the internal knee abduction moment (KAM) in walking has been widely studied. KAM has been shown to be closely associated with the development of medial knee osteoarthritis (OA). Despite the importance of the knee alignment, no studies have explored its effects on knee frontal plane biomechanics during stationary cycling. The purpose of this study was to examine the effects of varus knee alignment and using a toe-cage on the knee frontal plane biomechanics during stationary cycling. Eleven participants in each of the varus and neutral groups participated in the study. The participants performed in …
Promoting Extracellular Matrix Crosslinking In Synthetic Hydrogels, Marcos M. Manganare
Promoting Extracellular Matrix Crosslinking In Synthetic Hydrogels, Marcos M. Manganare
Masters Theses
The extracellular matrix (ECM) provides mechanical and biochemical support to tissues and cells. It is crucial for cell attachment, differentiation, and migration, as well as for ailment-associated processes such as angiogenesis, metastases and cancer development. An approach to study these phenomena is through emulation of the ECM by synthetic gels constructed of natural polymers, such as collagen and fibronectin, or simple but tunable materials such as poly(ethylene glycol) (PEG) crosslinked with short peptide sequences susceptible to digestion by metalloproteases and cell-binding domains. Our lab uses PEG gels to study cell behavior in three dimensions (3D). Although this system fosters cell …
Human Intracranial High Frequency Oscillation Detection Using Time Frequency Analysis And Its Relation To The Seizure Onset Zone, Riazul Islam
Masters Theses
One third of the patients diagnosed with focal epilepsy do not respond to antiepileptic drugs. For these patients the possible diagnosis options to give seizure freedom or at least reduce seizure frequencies significantly would be surgical resection or seizure interrupting implantable devices. The success of these procedures depends on accurate detection of the region causing seizure also known as epileptic zone. This requires detail pre-surgical evaluation including Invasive Video Electroencephalographic Monitoring (IVEM). The resulting great volume of intracranial Electroencephalography (iEEG) signal is visually examined by an expert epileptologist which can be time consuming, extremely complex, and not always effective. We …
Biodegradable Nano-Hybrid Polymer Composite Networks For Regulating Cellular Behavior, Charles Henley Sprague
Biodegradable Nano-Hybrid Polymer Composite Networks For Regulating Cellular Behavior, Charles Henley Sprague
Masters Theses
Photo-crosslinkable polymeric biomaterials have emerged in the field of biomedical research to promote tissue regeneration. For example, scaffolds that can be crosslinked and hardened in situ have been known to make suitable implant alternatives. Since injectable and photo-crosslinkable biomaterials offer the advantage of being minimally invasive, they have emerged to compete with autografts, a current highly invasive method to repair diseased tissue. A series of novel photo-crosslinkable, injectable, and biodegradable nano-hybrid polymers consisting of poly(ε-caprolactone fumarate) (PCLF) and polyhedral oligomeric silsesquioxane (POSS) has been synthesized in our laboratory via polycondensation. To engineer the material properties of the nano-hybrid networks, varied …
A Continous Rotary Actuation Mechanism For A Powered Hip Exoskeleton, Matthew C. Ryder
A Continous Rotary Actuation Mechanism For A Powered Hip Exoskeleton, Matthew C. Ryder
Masters Theses
This thesis presents a new mechanical design for an exoskeleton actuator to power the sagittal plane motion in the human hip. The device uses a DC motor to drive a Scotch yoke mechanism and series elasticity to take advantage of the cyclic nature of human gait and to reduce the maximum power and control requirements of the exoskeleton. The Scotch yoke actuator creates a position-dependent transmission that varies between 4:1 and infinity, with the peak transmission ratio aligned to the peak torque periods of the human gait cycle. Simulation results show that both the peak and average motor torque can …
Doping Of Fluorchlorozirconate And Borate-Silica Glass Ceramics For Medical Imaging And Fast Neutron Scintillation, Julie Elizabeth Swafford
Doping Of Fluorchlorozirconate And Borate-Silica Glass Ceramics For Medical Imaging And Fast Neutron Scintillation, Julie Elizabeth Swafford
Masters Theses
Borate silica glass ceramics were produced for neutron scintillation. The Glass ceramics were doped with europium fluoride [EuF2] and cerium chloride [CeCl3]. Isotopic lithium fluoride [6LiF] and boron oxide [10B2O3] were used in most samples while non-isotopic lithium fluoride [LiF] and boron oxide [ B2O3] were used in the rest. When exposed to a neutron beam, samples doped with europium fluoride [EuF2] scintillated while samples doped with cerium chloride [CeCl3] did not. This contradicts current literature on fast scintillation. What …
Computer Aided Diagnosis Of Oral Cancer: Using Time-Step Ct Images, Jonathan T. Scott
Computer Aided Diagnosis Of Oral Cancer: Using Time-Step Ct Images, Jonathan T. Scott
Masters Theses
"In medical imaging it is a very common practice to use a technique known as Time-Step imaging in patients who might develop cancer. Time-Step imaging it a very powerful technique, however it can lead to unmanageable amounts of image data. Previously the only way to search all of this data was to manually look through all of the files. This had to be done by trained professionals who knew what to look for within the images and make a judgment about the patient based on the images. This paper discusses the development of an algorithm to have a computer search …
Healing Of Bone Defects In A Rodent Calvarial Defect Model Using Strong Porous Bioactive Glass (13-93) Scaffolds, Yinan Lin
Masters Theses
"The main objective of this project was to evaluate the capacity of strong porous silicate (13-93) bioactive glass scaffolds prepared by a robocasting technique to regenerate bone and stimulate angiogenesis in a rat calvarial defect model. The scaffolds were created with the same grid-like microstructure but in a variety of formulations: (i) as-fabricated, (ii) pretreated in an aqueous phosphate solution to convert the glass surface to hydroxyapatite, (iii) loaded with bone morphogenetic protein-2 (BMP2) (1 µg per scaffold), and (iv) doped with copper (0.4-2.0 wt. % CuO). When compared to the as-fabricated scaffolds, the pretreated scaffolds enhanced bone regeneration at …
Freeform Extrusion Fabrication Of Titanium Fiber Reinforced 13-93 Bioactive Glass Scaffolds, Albin Thomas
Freeform Extrusion Fabrication Of Titanium Fiber Reinforced 13-93 Bioactive Glass Scaffolds, Albin Thomas
Masters Theses
"Although implants made with bioactive glass have shown promising results for bone repair, their application in repairing load-bearing long bones is limited due to their poor mechanical properties as compared to human bones. This thesis study is on freeform extrusion fabrication of silicate based 13-93 bioactive glass scaffolds reinforced with titanium fibers. A composite paste was prepared with 13-93 bioactive glass filled with titanium fibers (~16 µm in diameter and aspect ratio of ~250) having 0.1 to 0.4 vol. % of the bioactive glass scaffold. This paste was then filled into a syringe manually, and then extruded through a nozzle …
Computer Aided Detection Of Oral Lesions On Ct Images, Shaikat Mahmood Galib
Computer Aided Detection Of Oral Lesions On Ct Images, Shaikat Mahmood Galib
Masters Theses
"Oral lesions are important findings on computed tomography images. They are difficult to detect on CT images because of low contrast, arbitrary orientation of objects, complicated topology and lack of clear lines indicating lesions. In this thesis, a fully automatic method to detect oral lesions from dental CT images is proposed to identify (1) Closed boundary lesions and (2) Bone deformation lesions. Two algorithms were developed to recognize these two types of lesions, which cover most of the lesion types that can be found on CT images. The results were validated using a dataset of 52 patients. Using non training …
In Vitro Study Of Wound-Healing Capabilities Of Bioactive Glass Fibers Under Various Culture Conditions, Sisi Chen
Masters Theses
"Bioactive borate glass has been recognized to have both hard and soft tissue repair and regeneration capabilities through stimulating both osteogenesis and angiogenesis. However, the underlying physiological and cellular mechanism behind this function remains unclear. In this study, in vitro dynamic flow modules were designed to mimic the micro-environment near the vascular depletion and hyperplasia area in wound-healing regions, and were used to investigate the biocompatibility and functionality of borate glass nano-/micro-fibers. Glass-cell interactions were investigated either by dosing fibers to the upstream of or co-cultured with cells, and two types of borate glasses (with or without CuO/ZnO doped were …