Biomedical Engineering and Bioengineering Commons^™

Poly(Ester Amide) And Poly(Ethyl Glyoxylate) Nanoparticles For Controlled Drug Release, Amira Mohamed Moustafa

Electronic Thesis and Dissertation Repository

The objective of this research was to develop polymeric nanoparticles (NPs) having improved drug release properties for drug delivery. Poly(ester amide)s (PEAs) are promising biodegradable polymers. PEA NPs were prepared via emulsification-evaporation and salting-out methods and optimized through by varying different processing parameters. Polymer-model drug conjugates based on PEAs containing L-aspartic acid and rhodamine B were synthesized and used for NP preparation. Release behavior was studied and compared to a control system with physically encapsulated rhodamine B. It was shown that the release of rhodamine B from the covalent system did not show the burst effect and exhibited a slower …

Synthesis Of Multilayered Microparticles For Targeted Drug Delivery, Elizabeth Mercer

Open Access Theses

Microparticles have been shown to be valuable in targeted drug delivery which can lead to an increased dose delivered to a targeted location, reduced patient side effects, and improved patient outcomes. The designed multilayered microparticles have the clinical application to deliver hydrophobic drugs to a targeted area. The composition of the microparticles consists of a poly-lactic acid (PLA) polymer core surrounded by a polymeric shell composed of Poly(lactic-co-glycolic acid)-Poly(ethylene glycol)-Maleimide(PLGA-PEG-Mal). The maleimide promotes conjugation of the collagen binding peptide, SILY. Targeting to type I collagen allows for this microparticle system to attach to exposed collagen in atherosclerotic vessels.

A novel …

Curcumin-Loaded Magnetic Nanoaggregates Conjugated With Folic Acid For Targeted Cancer Treatment, Melessa Salem

Electronic Thesis and Dissertation Repository

Cancer has been, and still remains, one of the most complicated diseases to treat. As a result of the side effects experienced from current cancer treatment methods, there has been a growing interest in the development of targeted drug delivery systems that can destroy cancer cells, but render healthy tissue unharmed. To address this challenge, magnetite nanoaggregates were synthesized through the precipitation of iron oxide in the presence of polymers, conjugated with folic acid for folate targeting, and loaded with curcumin for cancer treatment. The resulting magnetite nanoparticles were 10 – 20 nm in size and the aggregates formed varied …

Evaluation Of Methods To Account For Release From Nanofiber Scaffolds, Jennifer Moy

Theses

Electrospinning is a common technique utilized to form fibers from the micro- to nanometer range. Nanofibers form through electrospinning can be utilized as scaffolds since the fiber structures are similar to the structures within the extracellular matrix. Researchers use additives, such as growth factors, to help facilitate cell proliferation and function. Also, researchers are attempting to use electrospun fibers for drug delivery and as wound dressings since the electrospun fibers have high surface area to volume ratio. In both situations, the release of either the additive or the drug needs to be controlled so that the fibers would release the …

Bioactivity And Cell-Mediated Targeting Of Multistage Nanoporous Silicon Particles, Jonathan O. Martinez

Dissertations & Theses (Open Access)

Progress in drug delivery approaches have not adequately translated into clinical advances in the diagnosis or treatment of inflammatory disorders (e.g., cancer). This disconnect is rooted in the inefficient delivery of imaging and therapeutic agents to the inflamed site upon systemic delivery. A multitude of biological barriers pose insurmountable obstacles limiting the ability of the agent to effectively reach and accumulate at the target site. Nanoparticles (NP) surfaced as potential vectors to encapsulate and deliver biological agents. However, even after surface decoration, NP have failed to evade biological barriers (i.e., MPS) and to accumulate at the tumor site at therapeutic …

Synthesis And Characterization Of Clickable Dendrimer Hydrogels For Ocular Drug Delivery, Jingfei Tian

Theses and Dissertations

Topical medication is a standard treatment for glaucoma. However, frequent dosing makes the therapy inconvenient and patient unfriendly. There is a great need to develop new topical formulations that provide long lasting noninvasive drug release. In this thesis, novel clickable dendrimer hydrogels for anti-glaucoma drug delivery were synthesized and characterized. Polyamidoamine (PAMAM) dendrimers have been widely applied for drug delivery. The physical characteristics they possess include monodispersity, water solubility, encapsulation ability, and a large number of surface groups. Polycationic PAMAM dendrimer G3 was surface modified with alkyne-PEG5-acid and then reacted with polyethylene glycol bisazide (PEG-BA, 1100 gmol-1) through click chemistry …

Development And Application Of Biomimetic Electrospun Nanofibers In Total Joint Replacement, Wei Song

Wayne State University Dissertations

Failure of osseointegration (direct anchorage of an implant by bone formation at the bone-implant surface) and implant infection (such as that caused by Staphylococcus aureus, S. aureus) are the two main causes of implant failure and loosening. There is a critical need for orthopedic implants that promote rapid osseointegration and prevent bacterial colonization, particularly when placed in bone compromised by disease or physiology of the patients. A better understanding of the key factors that influence cell fate decisions at the bone-implant interface is required. Our study is to develop a class of "bone-like" nanofibers (NFs) that promote osseointegration while preventing …