Biomedical Engineering and Bioengineering | Open Access Articles

Multifunctional Skin-Like Electronics For Quantitative, Clinical Monitoring Of Cutaneous Wound Healing, Yoshiaki Hattori, Leo Falgout, Woosik Lee, Sung-Young Jung, Emily Poon, Jung Woo Lee, Ilyoun Na, Amelia Geisler, Divya Sadhwani, Yihui Zhang, Yewang Su, Xiaoqi Wang, Zhuangjian Liu, Jing Xia, Huanyu Cheng, R. Chad Webb, Andrew P. Bonifas, Philip Won, Jae-Woong Jeong, Kyung-In Jang, Young Min Song, Beatrice Nardone, Michael Nodzenski, Jonathan A. Fan, Yonggang Huang, Dennis P. West, Amy S. Paller, Murad Alam, Woon-Hong Yeo, John. A. Rogers

Mechanical and Nuclear Engineering Publications

Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent …

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A Novel Myoelectric Training Device For Upper Limb Prostheses, Ryan Clingman, Peter Pidcoe

Biomedical Engineering Publications

A training system intended for myoelectric prosthetic hands for upper limb amputees was developed to assist in learning myoelectric control schemes and training muscle isolation. The trainer allowed a user to operate a remote controlled car by use of a control scheme commonly used in myoelectric prosthetic hands. The trainer was designed to be easy for therapists to use and more engaging for the user than current methods of signal training. Preliminary testing of the trainer was conducted with eight nonamputee adult volunteers. The results indicated that the trainer could be a useful tool for myoelectric training in upper limb …

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Impaired Bone Formation In Pdia3 Deficient Mice, Yun Wang, Alexandr Nizkorodov, Kelsie Riemenschneider, Christopher S. D. Lee, Rene Olivares-Navarrete, Zvi Schwartz, Barbara D. Boyan

Biomedical Engineering Publications

1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] is crucial for normal skeletal development and bone homeostasis. Protein disulfide isomerase family A, member 3 (PDIA3) mediates 1α,25(OH)2D3initiated-rapid membrane signaling in several cell types. To understand its role in regulating skeletal development, we generated Pdia3-deficient mice and examined the physiologic consequence of Pdia3-disruption in embryos and Pdia3+/− heterozygotes at different ages. No mice homozygous for the Pdia3-deletion were found at birth nor were there embryos after E12.5, indicating that targeted disruption of the Pdia3 gene resulted in early embryonic lethality.Pdia3-deficiency also resulted in skeletal manifestations as revealed by µCT analysis …

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Rock Inhibitor Is Not Required For Embryoid Body Formation From Singularized Human Embryonic Stem Cells, Giuseppe Pettinato, Wendy S. Vanden Berg-Foels, Ning Zhang, Xuejun Wen

Biomedical Engineering Publications

We report a technology to form human embryoid bodies (hEBs) from singularized human embryonic stem cells (hESCs) without the use of the p160 rho-associated coiled-coil kinase inhibitor (ROCKi) or centrifugation (spin). hEB formation was tested under four conditions: +ROCKi/+spin, +ROCKi/-spin, -ROCKi/+spin, and -ROCKi/-spin. Cell suspensions of BG01V/hOG and H9 hESC lines were pipetted into non-adherent hydrogel substrates containing defined microwell arrays. hEBs of consistent size and spherical geometry can be formed in each of the four conditions, including the -ROCKi/-spin condition. The hEBs formed under the -ROCKi/-spin condition differentiated to develop the three embryonic germ layers and tissues derived from …

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Full-Text Articles in Biomedical Engineering and Bioengineering

Mechanical and Nuclear Engineering Publications

A Novel Myoelectric Training Device For Upper Limb Prostheses, Ryan Clingman, Peter Pidcoe

Biomedical Engineering Publications

Impaired Bone Formation In Pdia3 Deficient Mice, Yun Wang, Alexandr Nizkorodov, Kelsie Riemenschneider, Christopher S. D. Lee, Rene Olivares-Navarrete, Zvi Schwartz, Barbara D. Boyan

Biomedical Engineering Publications

Rock Inhibitor Is Not Required For Embryoid Body Formation From Singularized Human Embryonic Stem Cells, Giuseppe Pettinato, Wendy S. Vanden Berg-Foels, Ning Zhang, Xuejun Wen

Biomedical Engineering Publications