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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 16 of 16
Full-Text Articles in Biomedical Engineering and Bioengineering
Single Cell Biophysics: Applications In Cardiomyocyte Mechanobiology And Stem Cell Mechanotransduction, Benjamin Edward Reese
Single Cell Biophysics: Applications In Cardiomyocyte Mechanobiology And Stem Cell Mechanotransduction, Benjamin Edward Reese
Doctoral Dissertations
While a great deal of work has been done to analyze cardiac dynamics and mechanics at the organ and tissue levels, there remains much less data regarding these metrics at the single cell level. Additionally, as fields such as regenerative medicine and tissue engineering are beginning to demonstrate greater therapeutic potential, the study and influence of stem cell mechanics on differentiation has become a major area of interest. For these reasons, along with the continued advancement of molecular techniques and assays, there is a growing need to develop functional assays that can integrate and bridge the findings from multiple length …
Unlocking The Secrets Of Multi-Flagellated Propulsion, Stefan Oma Nwandu-Vincent
Unlocking The Secrets Of Multi-Flagellated Propulsion, Stefan Oma Nwandu-Vincent
Doctoral Dissertations
In this work, unique high-speed imaging platforms and an array of theoretical analysis methods are used to thoroughly investigate eukaryotic multi-flagellated propulsion using Tritrichomonas foetus as a test case. Through experimental observations through our imaging system with superior resolution and capture rate exceeding that of previous studies, it was discovered for the first time that the T. foetus employs a strategy similar to that of the “run and tumble” strategies found in bacteria and Chlamydomonas; it has two distinct flagellar beating patterns that result in two different body swimming motions, linear and turning swimming.
These two flagella patterns were …
A Low-Power Approach For Front End Biological Signal Conditioning, Logan Smith Taylor
A Low-Power Approach For Front End Biological Signal Conditioning, Logan Smith Taylor
Masters Theses
In a lab-on-a-chip (LOC) application, the measurement of small analog signals such as local temperature variation often involves detection of very low-level signals in a noisy micro-scale environment. This is true for other biomedical monitoring systems as well. These systems observe various physiological parameters or electrochemical reactions that need to be tracked electrically. For temperature measurement pyroelectric transducers represent an efficient solution in terms of speed, sensitivity, and scale of integration, especially when prompt and accurate temperature monitoring is desired.
The ability to perform laboratory operations on a small scale using miniaturized LOC devices is a promising biosensing technique. The …
Joint Reaction Force And Contributions Of Surrounding Muscles To Knee Joint Load During Stair Ascent In Total Knee Replacement Patients And Healthy Individuals, Robert Jacob Rasnick
Joint Reaction Force And Contributions Of Surrounding Muscles To Knee Joint Load During Stair Ascent In Total Knee Replacement Patients And Healthy Individuals, Robert Jacob Rasnick
Masters Theses
Total knee replacement (TKR) is commonly used to correct end stage knee osteoarthritis (OA) of the knee joint. Unfortunately, difficulty with stair climbing has been seen to exist, prolonging the challenges of TKR patents. Complete understanding of loading at the knee is of great interest in order to aid patient populations, implant manufacturers, rehabilitation, and future research. The outcome of a TKR is intended to reestablish normal motion and loading of the knee. Musculoskeletal modeling provides a means to accurately approximate joint loading and the corresponding muscle contributions during a movement.
The purpose of the present study was to examine …
Mathematically Modeling Fetal Electrocardiograms, Samuel Estes, Kiersten Utsey, Erick Kalobwe
Mathematically Modeling Fetal Electrocardiograms, Samuel Estes, Kiersten Utsey, Erick Kalobwe
Pursuit - The Journal of Undergraduate Research at The University of Tennessee
Abstract
Some of the most common and fatal birth defects are those related to the heart. In adults, possible heart conditions are often identified through the use of an electrocardiogram (ECG). However, due to the presence of other signals and noise in the recording, fetal eletrocardiography has not yet proven effective in diagnosing these defects. This paper develops a mathematical model of three-dimensional heart vector trajectories, which was used to generate synthetic maternal and fetal ECG signals. The dipole model is a useful simplification in which the electrical activity of the heart is viewed as a single time-varying vector originating …
Wirelesseeg: Data Aquisition + Handheld Device, Michael Dylan Snowden, Madeline Threatt, Brent Mcferrin, David Platillero, Karsten Solies, Lindsey Hopf
Wirelesseeg: Data Aquisition + Handheld Device, Michael Dylan Snowden, Madeline Threatt, Brent Mcferrin, David Platillero, Karsten Solies, Lindsey Hopf
Chancellor’s Honors Program Projects
No abstract provided.
The Hemo-Quik, Michelle Morin
The Hemo-Quik, Michelle Morin
Chancellor’s Honors Program Projects
No abstract provided.
Engineering Bacterial Cellulose Scaffold And Its Biomimetic Composites For Bone And Cartilage Tissue Regeneration, Pelagie Marlene Favi
Engineering Bacterial Cellulose Scaffold And Its Biomimetic Composites For Bone And Cartilage Tissue Regeneration, Pelagie Marlene Favi
Doctoral Dissertations
A very promising approach to quickly and safely restore normal function to extensively damages and diseases bone and cartilage tissues is the regeneration of these injured tissues using an engineered support scaffold. This dissertation research focuses on the development and evaluation of native bacterial cellulose (BC) and chemically modified BCs as potential biomaterials for bone and cartilage regeneration using equine-derived bone marrow mesenchymal stem cells (EqMSCs).
The ability of native BC scaffold to maintain cell proliferation, viability, and in vitro differentiation of the seeded EqMSCs for application in bone and cartilage tissue engineering was studied. BC morphology was characterized using …
Modeling, Analysis, And Control Of A Mobile Robot For In Vivo Fluoroscopy Of Human Joints During Natural Movements, Matthew A. Young
Modeling, Analysis, And Control Of A Mobile Robot For In Vivo Fluoroscopy Of Human Joints During Natural Movements, Matthew A. Young
Doctoral Dissertations
In this dissertation, the modeling, analysis and control of a multi-degree of freedom (mdof) robotic fluoroscope was investigated. A prototype robotic fluoroscope exists, and consists of a 3 dof mobile platform with two 2 dof Cartesian manipulators mounted symmetrically on opposite sides of the platform. One Cartesian manipulator positions the x-ray generator and the other Cartesian manipulator positions the x-ray imaging device. The robotic fluoroscope is used to x-ray skeletal joints of interest of human subjects performing natural movement activities. In order to collect the data, the Cartesian manipulators must keep the x-ray generation and imaging devices accurately aligned while …
Dynamic Simulations And Data Mining Of Single-Leg Jump Landing: Implications For Anterior Cruciate Ligament Injury Prevention, Kristin Denise Morgan
Dynamic Simulations And Data Mining Of Single-Leg Jump Landing: Implications For Anterior Cruciate Ligament Injury Prevention, Kristin Denise Morgan
Doctoral Dissertations
It is estimated that 400,000 anterior cruciate ligament (ACL) injuries occur in the United States each year with the cost of ACL reconstruction surgery and rehabilitation exceeding $1 billion annually. The majority of ACL injuries are non-contact injuries occurring during cutting and jump landing movements. Because the majority of the injuries are non-contact injuries there is the potential to develop programs to reduce the risk of injury. Given our understanding of the joint kinematics and kinetics that place an individual at high risk for ACL, researchers have developed neuromuscular training programs that focus on improving muscle function in order to …
Dynamic Complexity And Causality Analysis Of Scalp Eeg For Detection Of Cognitive Deficits, Joseph Curtis Mcbride
Dynamic Complexity And Causality Analysis Of Scalp Eeg For Detection Of Cognitive Deficits, Joseph Curtis Mcbride
Doctoral Dissertations
This dissertation explores the potential of scalp electroencephalography (EEG) for the detection and evaluation of neurological deficits due to moderate/severe traumatic brain injury (TBI), mild cognitive impairment (MCI), and early Alzheimer’s disease (AD). Neurological disorders often cannot be accurately diagnosed without the use of advanced imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Non-quantitative task-based examinations are also used. None of these techniques, however, are typically performed in the primary care setting. Furthermore, the time and expense involved often deters physicians from performing them, leading to potential worse prognoses for patients.
If …
Sensitivity Analysis Of A Leaf Photosynthesis-Stomatal Resistance Model, Gabriel A. Garcia
Sensitivity Analysis Of A Leaf Photosynthesis-Stomatal Resistance Model, Gabriel A. Garcia
Chancellor’s Honors Program Projects
No abstract provided.
Design Of Surgical End Effectors For Robotic Parallel Continuum Manipulators, Andrew L. Orekhov, Caroline E. Bryson, D. Caleb Rucker
Design Of Surgical End Effectors For Robotic Parallel Continuum Manipulators, Andrew L. Orekhov, Caroline E. Bryson, D. Caleb Rucker
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
No abstract provided.
An Investigation Of Diagnostic And Treatment Methods For Patients Suffering From Arachnoid Cysts, Helene Marie Rynczak, John F. Taylor
An Investigation Of Diagnostic And Treatment Methods For Patients Suffering From Arachnoid Cysts, Helene Marie Rynczak, John F. Taylor
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Arachnoid cysts are congenital, fluid-filled lesions located in the head. While most are asymptomatic, arachnoid cysts can cause debilitating symptoms in patients, including headaches, developmental delay, seizures, and physical disabilities. Current diagnostic and treatment methods are based on a trial and error approach with limited options available to patients and doctors. This research aims to identify areas for the development of innovative diagnostic and treatment methods to improve the quality of life for patients suffering from symptomatic arachnoid cysts.
Our research project began with the investigation of arachnoid cyst prevalence, correlation of symptoms with cyst location and the effectiveness of …
Sensitivity Analysis Of A Photosynthesis-Stomatal Resistance Model, Gabriel A. Garcia
Sensitivity Analysis Of A Photosynthesis-Stomatal Resistance Model, Gabriel A. Garcia
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Abstract/Poster
Bowen Ratio Energy Balance Measurement Of Carbon Dioxide (Co2) Fluxes Of No-Till And Conventional Tillage Agriculture In Lesotho, Debra Blumberg O'Dell, Thomas J. Sauer, Bruce B. Hicks, Dayton M. Lambert, David R. Smith, Wendy Bruns, August Basson, Makoala V. Marake, Forbes Walker, Michael D. Wilcox Jr., Neal Samuel Eash
Bowen Ratio Energy Balance Measurement Of Carbon Dioxide (Co2) Fluxes Of No-Till And Conventional Tillage Agriculture In Lesotho, Debra Blumberg O'Dell, Thomas J. Sauer, Bruce B. Hicks, Dayton M. Lambert, David R. Smith, Wendy Bruns, August Basson, Makoala V. Marake, Forbes Walker, Michael D. Wilcox Jr., Neal Samuel Eash
Biosystems Engineering and Soil Science Publications and Other Works
Global food demand requires that soils be used intensively for agriculture, but how these soils are managed greatly impacts soil fluxes of carbon dioxide (CO2). Soil management practices can cause carbon to be either sequestered or emitted, with corresponding uncertain influence on atmospheric CO2 concentrations. The situation is further complicated by the lack of CO2 flux measurements for African subsistence farms. For widespread application in remote areas, a simple experimental methodology is desired. As a first step, the present study investigated the use of Bowen Ratio Energy Balance (BREB) instrumentation to measure the energy balance and …