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Sustained Release Of Estrogens From Pegylated Nanoparticles For Treatment Of Secondary Spinal Cord Injury, John Barry
Sustained Release Of Estrogens From Pegylated Nanoparticles For Treatment Of Secondary Spinal Cord Injury, John Barry
All Dissertations
Spinal Cord Injury (SCI) is a debilitating condition which causes neurological damage and can result in paralysis. SCI results in immediate mechanical damage to the spinal cord, but secondary injuries due to inflammation, oxidative damage, and activated biochemical pathways leading to apoptosis exacerbate the injury. The only currently available treatment, methylprednisolone, is controversial because there is no convincing data to support its therapeutic efficacy for SCI treatment. In the absence of an effective SCI treatment option, 17β-estradiol has gained significant attention for its anti-oxidant, anti-inflammatory, and anti-apoptotic abilities, all events associated with secondary. Sadly, 17β-estradiol is associated with systemic adverse …
Diffusion Tensor Imaging Of The Central Nervous System Following An Injury To The Spinal Cord And Cell Transplant, Michael Jirjis
Diffusion Tensor Imaging Of The Central Nervous System Following An Injury To The Spinal Cord And Cell Transplant, Michael Jirjis
Dissertations (1934 -)
The purpose of this dissertation research was to characterize the use of magnetic resonance diffusion tensor imaging (DTI) as a diagnostic and prognostic tool in understanding the changes that occur throughout the spinal cord and brain following a spinal cord injury (SCI) and following stem cell transplant. The diffusion of water inside the nervous system is dramatically altered around the lesion site following a traumatic SCI. However, following damage to the spinal cord, little is known about the diffusion characteristics away from an injury and even less is understood about DTI's sensitivity to structural changes that occur following regenerative transplant …